Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of research, the treatment options for lung cancer patients remain inadequate, either to offer a cure or even a substantial survival advantage owing to its intrinsic resistance to chemotherapy. Our results propose t...
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oai:doaj.org-article:48957223d22c4bd3bae714c655194b962021-11-18T08:15:41ZCapsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.1932-620310.1371/journal.pone.0099743https://doaj.org/article/48957223d22c4bd3bae714c655194b962014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24926985/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of research, the treatment options for lung cancer patients remain inadequate, either to offer a cure or even a substantial survival advantage owing to its intrinsic resistance to chemotherapy. Our results propose the effectiveness of capsaicin in down-regulating VEGF expression in non-small cell lung carcinoma (NSCLC) cells in hypoxic environment. Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1α degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1α nuclear localization. Such signal-modulations consequently down regulated VEGF expression to thwart endothelial cell migration and network formation, pre-requisites of angiogenesis in tumor micro-environment. The above results advocate the candidature of capsaicin in exclusively targeting angiogenesis by down-regulating VEGF in tumor cells to achieve more efficient and cogent therapy of resistant NSCLC.Samik ChakrabortyArghya AdhikaryMinakshi MazumdarShravanti MukherjeePushpak BhattacharjeeDeblina GuhaTathagata ChoudhuriSamit ChattopadhyayGaurisankar SaAparna SenTanya DasPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99743 (2014) |
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Medicine R Science Q |
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Medicine R Science Q Samik Chakraborty Arghya Adhikary Minakshi Mazumdar Shravanti Mukherjee Pushpak Bhattacharjee Deblina Guha Tathagata Choudhuri Samit Chattopadhyay Gaurisankar Sa Aparna Sen Tanya Das Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. |
| description |
Lung cancer is the leading cause of cancer-related deaths worldwide. Despite decades of research, the treatment options for lung cancer patients remain inadequate, either to offer a cure or even a substantial survival advantage owing to its intrinsic resistance to chemotherapy. Our results propose the effectiveness of capsaicin in down-regulating VEGF expression in non-small cell lung carcinoma (NSCLC) cells in hypoxic environment. Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1α degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1α nuclear localization. Such signal-modulations consequently down regulated VEGF expression to thwart endothelial cell migration and network formation, pre-requisites of angiogenesis in tumor micro-environment. The above results advocate the candidature of capsaicin in exclusively targeting angiogenesis by down-regulating VEGF in tumor cells to achieve more efficient and cogent therapy of resistant NSCLC. |
| format |
article |
| author |
Samik Chakraborty Arghya Adhikary Minakshi Mazumdar Shravanti Mukherjee Pushpak Bhattacharjee Deblina Guha Tathagata Choudhuri Samit Chattopadhyay Gaurisankar Sa Aparna Sen Tanya Das |
| author_facet |
Samik Chakraborty Arghya Adhikary Minakshi Mazumdar Shravanti Mukherjee Pushpak Bhattacharjee Deblina Guha Tathagata Choudhuri Samit Chattopadhyay Gaurisankar Sa Aparna Sen Tanya Das |
| author_sort |
Samik Chakraborty |
| title |
Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. |
| title_short |
Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. |
| title_full |
Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. |
| title_fullStr |
Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. |
| title_full_unstemmed |
Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis. |
| title_sort |
capsaicin-induced activation of p53-smar1 auto-regulatory loop down-regulates vegf in non-small cell lung cancer to restrain angiogenesis. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/48957223d22c4bd3bae714c655194b96 |
| work_keys_str_mv |
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