Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans

Abstract A coordinated pattern of multi-muscle activation is essential to produce efficient reaching trajectories. Disruption of these coordinated activation patterns, termed synergies, is evident following stroke and results in reaching deficits; however, preclinical investigation of this phenomeno...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gustavo Balbinot, Clarissa Pedrini Schuch, Matthew S. Jeffers, Matthew W. McDonald, Jessica M. Livingston-Thomas, Dale Corbett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4895a50ebfa6404cba7816bc28ec40a3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:4895a50ebfa6404cba7816bc28ec40a3
record_format	dspace
spelling	oai:doaj.org-article:4895a50ebfa6404cba7816bc28ec40a32021-12-02T15:09:02ZPost-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans10.1038/s41598-018-27101-02045-2322https://doaj.org/article/4895a50ebfa6404cba7816bc28ec40a32018-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-27101-0https://doaj.org/toc/2045-2322Abstract A coordinated pattern of multi-muscle activation is essential to produce efficient reaching trajectories. Disruption of these coordinated activation patterns, termed synergies, is evident following stroke and results in reaching deficits; however, preclinical investigation of this phenomenon has been largely ignored. Furthermore, traditional outcome measures of post-stroke performance seldom distinguish between impairment restitution and compensatory movement strategies. We sought to address this by using kinematic analysis to characterize reaching movements and kinematic synergies of rats performing the Montoya staircase task, before and after ischemic stroke. Synergy was defined as the simultaneous movement of the wrist and other proximal forelimb joints (i.e. shoulder, elbow) during reaching. Following stroke, rats exhibited less individuation between joints, moving the affected limb more as a unit. Moreover, abnormal flexor synergy characterized by concurrent elbow flexion, shoulder adduction, and external rotation was evident. These abnormalities ultimately led to inefficient and unstable reaching trajectories, and decreased reaching performance (pellets retrieved). The observed reaching abnormalities in this preclinical stroke model are similar to those classically observed in humans. This highlights the potential of kinematic analysis to better align preclinical and clinical outcome measures, which is essential for developing future rehabilitation strategies following stroke.Gustavo BalbinotClarissa Pedrini SchuchMatthew S. JeffersMatthew W. McDonaldJessica M. Livingston-ThomasDale CorbettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gustavo Balbinot Clarissa Pedrini Schuch Matthew S. Jeffers Matthew W. McDonald Jessica M. Livingston-Thomas Dale Corbett Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
description	Abstract A coordinated pattern of multi-muscle activation is essential to produce efficient reaching trajectories. Disruption of these coordinated activation patterns, termed synergies, is evident following stroke and results in reaching deficits; however, preclinical investigation of this phenomenon has been largely ignored. Furthermore, traditional outcome measures of post-stroke performance seldom distinguish between impairment restitution and compensatory movement strategies. We sought to address this by using kinematic analysis to characterize reaching movements and kinematic synergies of rats performing the Montoya staircase task, before and after ischemic stroke. Synergy was defined as the simultaneous movement of the wrist and other proximal forelimb joints (i.e. shoulder, elbow) during reaching. Following stroke, rats exhibited less individuation between joints, moving the affected limb more as a unit. Moreover, abnormal flexor synergy characterized by concurrent elbow flexion, shoulder adduction, and external rotation was evident. These abnormalities ultimately led to inefficient and unstable reaching trajectories, and decreased reaching performance (pellets retrieved). The observed reaching abnormalities in this preclinical stroke model are similar to those classically observed in humans. This highlights the potential of kinematic analysis to better align preclinical and clinical outcome measures, which is essential for developing future rehabilitation strategies following stroke.
format	article
author	Gustavo Balbinot Clarissa Pedrini Schuch Matthew S. Jeffers Matthew W. McDonald Jessica M. Livingston-Thomas Dale Corbett
author_facet	Gustavo Balbinot Clarissa Pedrini Schuch Matthew S. Jeffers Matthew W. McDonald Jessica M. Livingston-Thomas Dale Corbett
author_sort	Gustavo Balbinot
title	Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
title_short	Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
title_full	Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
title_fullStr	Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
title_full_unstemmed	Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
title_sort	post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4895a50ebfa6404cba7816bc28ec40a3
work_keys_str_mv	AT gustavobalbinot poststrokekinematicanalysisinratsrevealssimilarreachingabnormalitiesashumans AT clarissapedrinischuch poststrokekinematicanalysisinratsrevealssimilarreachingabnormalitiesashumans AT matthewsjeffers poststrokekinematicanalysisinratsrevealssimilarreachingabnormalitiesashumans AT matthewwmcdonald poststrokekinematicanalysisinratsrevealssimilarreachingabnormalitiesashumans AT jessicamlivingstonthomas poststrokekinematicanalysisinratsrevealssimilarreachingabnormalitiesashumans AT dalecorbett poststrokekinematicanalysisinratsrevealssimilarreachingabnormalitiesashumans
_version_	1718387934707580928

Post-stroke kinematic analysis in rats reveals similar reaching abnormalities as humans

Ejemplares similares