Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile...

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Autores principales:	Liise-anne Pirofski, Arturo Casadevall
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	COVID viral pathogenesis virus Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/489831b564b945739fa55130e4c1b470
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spelling	oai:doaj.org-article:489831b564b945739fa55130e4c1b4702021-11-15T15:56:45ZPathogenesis of COVID-19 from the Perspective of the Damage-Response Framework10.1128/mBio.01175-202150-7511https://doaj.org/article/489831b564b945739fa55130e4c1b4702020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01175-20https://doaj.org/toc/2150-7511ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease.Liise-anne PirofskiArturo CasadevallAmerican Society for MicrobiologyarticleCOVIDviral pathogenesisvirusMicrobiologyQR1-502ENmBio, Vol 11, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID viral pathogenesis virus Microbiology QR1-502
spellingShingle	COVID viral pathogenesis virus Microbiology QR1-502 Liise-anne Pirofski Arturo Casadevall Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
description	ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents the medical community with a significant challenge. COVID-19 is an entirely new disease with disparate clinical manifestations that are difficult to reconcile with a single pathogenic principle. Here, we explain how the flexible paradigm of the “damage-response framework” (DRF) of microbial pathogenesis can organize the varied manifestations of COVID-19 into a synthesis that accounts for differences in susceptibility of vulnerable populations as well as for differing manifestations of COVID-19 disease. By focusing on mechanisms of host damage, particularly immune-mediated damage, the DRF provides a lens to understand COVID-19 pathogenesis and to consider how potential therapies could alter the outcome of this disease.
format	article
author	Liise-anne Pirofski Arturo Casadevall
author_facet	Liise-anne Pirofski Arturo Casadevall
author_sort	Liise-anne Pirofski
title	Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
title_short	Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
title_full	Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
title_fullStr	Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
title_full_unstemmed	Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework
title_sort	pathogenesis of covid-19 from the perspective of the damage-response framework
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/489831b564b945739fa55130e4c1b470
work_keys_str_mv	AT liiseannepirofski pathogenesisofcovid19fromtheperspectiveofthedamageresponseframework AT arturocasadevall pathogenesisofcovid19fromtheperspectiveofthedamageresponseframework
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Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework

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