Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy

Metal nanoparticles have been widely used in the treatment of diabetic wounds owing to their proven antibacterial activity and enhanced wound healing effects. Therefore, in this review, we discuss the use of metal nanoparticles in managing diabetic wounds, mainly silver nanoparticles (AgNPs), gold n...

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Autores principales:	Nor Azlan Ahmad Yasser Hamdi, Katas Haliza, Mh Busra Mohd Fauzi, Salleh Nur Atiqah Mohamad, Smandri Ali
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	diabetes mellitus chronic wound nanocomposites, antimicrobial activity diabetic ulcer Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
Acceso en línea:	https://doaj.org/article/48a0094db0e44060a8ea9ec8b09ef744
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spelling	oai:doaj.org-article:48a0094db0e44060a8ea9ec8b09ef7442021-12-05T14:10:57ZMetal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy2191-909710.1515/ntrev-2021-0046https://doaj.org/article/48a0094db0e44060a8ea9ec8b09ef7442021-07-01T00:00:00Zhttps://doi.org/10.1515/ntrev-2021-0046https://doaj.org/toc/2191-9097Metal nanoparticles have been widely used in the treatment of diabetic wounds owing to their proven antibacterial activity and enhanced wound healing effects. Therefore, in this review, we discuss the use of metal nanoparticles in managing diabetic wounds, mainly silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and zinc nanoparticles (ZnO nanoparticles), as well as their combination with biomaterials such as chitosan, bacterial cellulose, growth factors, etc. The combination of metal nanoparticles and biomaterials reportedly halts the growth and multiplication of bacterial strains commonly involved in diabetic wounds, including gram-positive (Staphylococcus aureus and Acinetobacter calcoaceticus) and gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae). Furthermore, these combinations have demonstrated enhanced wound healing of diabetic wounds during in vitro and in vivo studies. Additionally, we highlighted the barriers and challenges associated with the use of metal nanoparticles, including toxicities. Moreover, toxicities were mainly related to the method of synthesis employed, as well as the physical characteristics of nanoparticles, including size, shape, surface charge, and morphology. Collectively, dual-therapy composed of metal nanoparticles and biomaterials has been shown to promote wound healing and can be developed as a promising future therapy for better outcomes in diabetic wound healing.Nor Azlan Ahmad Yasser HamdiKatas HalizaMh Busra Mohd FauziSalleh Nur Atiqah MohamadSmandri AliDe Gruyterarticlediabetes mellituschronic woundnanocomposites, antimicrobial activitydiabetic ulcerTechnologyTChemical technologyTP1-1185Physical and theoretical chemistryQD450-801ENNanotechnology Reviews, Vol 10, Iss 1, Pp 653-670 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus chronic wound nanocomposites, antimicrobial activity diabetic ulcer Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801
spellingShingle	diabetes mellitus chronic wound nanocomposites, antimicrobial activity diabetic ulcer Technology T Chemical technology TP1-1185 Physical and theoretical chemistry QD450-801 Nor Azlan Ahmad Yasser Hamdi Katas Haliza Mh Busra Mohd Fauzi Salleh Nur Atiqah Mohamad Smandri Ali Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
description	Metal nanoparticles have been widely used in the treatment of diabetic wounds owing to their proven antibacterial activity and enhanced wound healing effects. Therefore, in this review, we discuss the use of metal nanoparticles in managing diabetic wounds, mainly silver nanoparticles (AgNPs), gold nanoparticles (AuNPs), and zinc nanoparticles (ZnO nanoparticles), as well as their combination with biomaterials such as chitosan, bacterial cellulose, growth factors, etc. The combination of metal nanoparticles and biomaterials reportedly halts the growth and multiplication of bacterial strains commonly involved in diabetic wounds, including gram-positive (Staphylococcus aureus and Acinetobacter calcoaceticus) and gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae). Furthermore, these combinations have demonstrated enhanced wound healing of diabetic wounds during in vitro and in vivo studies. Additionally, we highlighted the barriers and challenges associated with the use of metal nanoparticles, including toxicities. Moreover, toxicities were mainly related to the method of synthesis employed, as well as the physical characteristics of nanoparticles, including size, shape, surface charge, and morphology. Collectively, dual-therapy composed of metal nanoparticles and biomaterials has been shown to promote wound healing and can be developed as a promising future therapy for better outcomes in diabetic wound healing.
format	article
author	Nor Azlan Ahmad Yasser Hamdi Katas Haliza Mh Busra Mohd Fauzi Salleh Nur Atiqah Mohamad Smandri Ali
author_facet	Nor Azlan Ahmad Yasser Hamdi Katas Haliza Mh Busra Mohd Fauzi Salleh Nur Atiqah Mohamad Smandri Ali
author_sort	Nor Azlan Ahmad Yasser Hamdi
title	Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
title_short	Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
title_full	Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
title_fullStr	Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
title_full_unstemmed	Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy
title_sort	metal nanoparticles and biomaterials: the multipronged approach for potential diabetic wound therapy
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/48a0094db0e44060a8ea9ec8b09ef744
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Metal nanoparticles and biomaterials: The multipronged approach for potential diabetic wound therapy

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