Physical Training Increases Erythroferrone Levels in Men

Intense physical activity contributes to an increased demand for red blood cells, which transport oxygen to working muscles. The purpose of this study was to assess the concentration of erythroferrone (ERFE), the novel marker of erythroid activity in athletes, during the beginning of their training...

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Autores principales:	Inga Dziembowska, Małgorzata Wójcik, Jakub Bukowski, Ewa Żekanowska
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	erythropoietin erythroferrone physical activity Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/48a299ca6fd347fe9a872944f12b42dc
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id	oai:doaj.org-article:48a299ca6fd347fe9a872944f12b42dc
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spelling	oai:doaj.org-article:48a299ca6fd347fe9a872944f12b42dc2021-11-25T16:48:14ZPhysical Training Increases Erythroferrone Levels in Men10.3390/biology101112152079-7737https://doaj.org/article/48a299ca6fd347fe9a872944f12b42dc2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-7737/10/11/1215https://doaj.org/toc/2079-7737Intense physical activity contributes to an increased demand for red blood cells, which transport oxygen to working muscles. The purpose of this study was to assess the concentration of erythroferrone (ERFE), the novel marker of erythroid activity in athletes, during the beginning of their training season. The study group consisted of 39 athletes aged 23.24 ± 3.77 years. The study was carried out during the athletes’ preparatory period of the training cycle. The control group consisted of 34 healthy men aged 22.33 ± 2.77 years. The erythropoietic activity was evaluated by determining athletes’ concentrations of erythropoietin (EPO) and erythroferrone (ERFE). The level of physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). In the athletes’ group, we observed higher concentrations of EPO (Me = 12.65 mIU/mL) and ERFE (40.00 pg/mL) compared to the control group (EPO: Me = 5.74 mIU/ml, <i>p</i> = 0.001; ERFE: Me = 25.50 pg/mL, <i>p</i> = 0.0034). The average intensity of physical exercise significantly differentiated the participants as far as EPO and ERFE concentrations. These results suggest that intense physical activity, at least at the beginning of the training season, may stimulate EPO production, which increases ERFE release. This seems to be an adaptative mechanism that provides adequate iron for enhanced erythropoiesis.Inga DziembowskaMałgorzata WójcikJakub BukowskiEwa ŻekanowskaMDPI AGarticleerythropoietinerythroferronephysical activityBiology (General)QH301-705.5ENBiology, Vol 10, Iss 1215, p 1215 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	erythropoietin erythroferrone physical activity Biology (General) QH301-705.5
spellingShingle	erythropoietin erythroferrone physical activity Biology (General) QH301-705.5 Inga Dziembowska Małgorzata Wójcik Jakub Bukowski Ewa Żekanowska Physical Training Increases Erythroferrone Levels in Men
description	Intense physical activity contributes to an increased demand for red blood cells, which transport oxygen to working muscles. The purpose of this study was to assess the concentration of erythroferrone (ERFE), the novel marker of erythroid activity in athletes, during the beginning of their training season. The study group consisted of 39 athletes aged 23.24 ± 3.77 years. The study was carried out during the athletes’ preparatory period of the training cycle. The control group consisted of 34 healthy men aged 22.33 ± 2.77 years. The erythropoietic activity was evaluated by determining athletes’ concentrations of erythropoietin (EPO) and erythroferrone (ERFE). The level of physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). In the athletes’ group, we observed higher concentrations of EPO (Me = 12.65 mIU/mL) and ERFE (40.00 pg/mL) compared to the control group (EPO: Me = 5.74 mIU/ml, <i>p</i> = 0.001; ERFE: Me = 25.50 pg/mL, <i>p</i> = 0.0034). The average intensity of physical exercise significantly differentiated the participants as far as EPO and ERFE concentrations. These results suggest that intense physical activity, at least at the beginning of the training season, may stimulate EPO production, which increases ERFE release. This seems to be an adaptative mechanism that provides adequate iron for enhanced erythropoiesis.
format	article
author	Inga Dziembowska Małgorzata Wójcik Jakub Bukowski Ewa Żekanowska
author_facet	Inga Dziembowska Małgorzata Wójcik Jakub Bukowski Ewa Żekanowska
author_sort	Inga Dziembowska
title	Physical Training Increases Erythroferrone Levels in Men
title_short	Physical Training Increases Erythroferrone Levels in Men
title_full	Physical Training Increases Erythroferrone Levels in Men
title_fullStr	Physical Training Increases Erythroferrone Levels in Men
title_full_unstemmed	Physical Training Increases Erythroferrone Levels in Men
title_sort	physical training increases erythroferrone levels in men
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48a299ca6fd347fe9a872944f12b42dc
work_keys_str_mv	AT ingadziembowska physicaltrainingincreaseserythroferronelevelsinmen AT małgorzatawojcik physicaltrainingincreaseserythroferronelevelsinmen AT jakubbukowski physicaltrainingincreaseserythroferronelevelsinmen AT ewazekanowska physicaltrainingincreaseserythroferronelevelsinmen
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Physical Training Increases Erythroferrone Levels in Men

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