Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia

Eyosiyas Temesgen, 1 Haile Weldu, 2 Kefyalew Ayalew Getahun, 3 Tezera Jemere Aragaw 3 1Jewish Voice Ministries International, Addis Ababa, Ethiopia; 2Shiraro Hospital, North Tigray, Ethiopia; 3Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethio...

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Autores principales:	Temesgen E, Weldu H, Ayalew Getahun K, Jemere Aragaw T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	pep npep hiv health care workers university of gondar comprehensive and specialized hospital. Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/48a559636970484bb04c5035e2203251
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spelling	oai:doaj.org-article:48a559636970484bb04c5035e22032512021-12-02T09:55:06ZEvaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia1179-1373https://doaj.org/article/48a559636970484bb04c5035e22032512020-01-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-post-exposure-prophylaxis-utilization-among-human-immuno-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Eyosiyas Temesgen, 1 Haile Weldu, 2 Kefyalew Ayalew Getahun, 3 Tezera Jemere Aragaw 3 1Jewish Voice Ministries International, Addis Ababa, Ethiopia; 2Shiraro Hospital, North Tigray, Ethiopia; 3Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Kefyalew Ayalew Getahun Email kefayalew@gmail.comBackground: Human immunodeficiency virus (HIV) infection is a serious public health problem costing the lives of many people including healthcare workers worldwide. Ethiopia is one of the most seriously affected countries in sub-Saharan Africa, with a large number of people who are living with HIV/AIDS and AIDS -related deaths. Prevention of the virus transmission through the appropriate utilization of post exposure prophylaxis is one of the major strategies. Therefore, the aim of this study was to evaluate the utilization of post-exposure prophylaxis (PEP) among victims of HIV at the University of Gondar Comprehensive Specialized Hospital, north-west Ethiopia. A retrospective cross-sectional study was conducted from May 17, 2018, to May 24, 2018 and descriptive statistics were carried out to analyze the Data using SPSS version 20.Results: From a total of 309 patients PEP was prescribed during the study period, of whom 239 (77.34%) were occupational victims and 55 (17.8%) were rape victims, with one missing data. Occupational victims were exposed by blood and blood product splashes and nurses and physicians were exposed almost equally, 14.24% and 13.92%, respectively. The majority of the victims were exposed at a health facility. Two hundred and eighty-five (92.23%) victims received prescriptions containing three-drug regimens, tenofovir + lamivudine + efavirenz, followed by 9 victims (2.91%) with two-drug regimens; zidovudine + lamivudine. There are no follow-up mechanisms as a result the completion rate and the outcome of PEP was not determined.Conclusion: PEP was initiated within 72 hr, most within 24 hr. The adherence was unknown with poor follow-up despite the strong recommendations of the national and WHO guidelines.Keywords: PEP, PEP utilization, nPEP, HIV, healthcare workers, University of Gondar Comprehensive Specialized HospitalTemesgen EWeldu HAyalew Getahun KJemere Aragaw TDove Medical Pressarticlepepnpephivhealth care workersuniversity of gondar comprehensive and specialized hospital.Immunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 12, Pp 59-67 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	pep npep hiv health care workers university of gondar comprehensive and specialized hospital. Immunologic diseases. Allergy RC581-607
spellingShingle	pep npep hiv health care workers university of gondar comprehensive and specialized hospital. Immunologic diseases. Allergy RC581-607 Temesgen E Weldu H Ayalew Getahun K Jemere Aragaw T Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia
description	Eyosiyas Temesgen, 1 Haile Weldu, 2 Kefyalew Ayalew Getahun, 3 Tezera Jemere Aragaw 3 1Jewish Voice Ministries International, Addis Ababa, Ethiopia; 2Shiraro Hospital, North Tigray, Ethiopia; 3Department of Pharmacology, College of Medicine and Health Sciences, University of Gondar, Gondar, EthiopiaCorrespondence: Kefyalew Ayalew Getahun Email kefayalew@gmail.comBackground: Human immunodeficiency virus (HIV) infection is a serious public health problem costing the lives of many people including healthcare workers worldwide. Ethiopia is one of the most seriously affected countries in sub-Saharan Africa, with a large number of people who are living with HIV/AIDS and AIDS -related deaths. Prevention of the virus transmission through the appropriate utilization of post exposure prophylaxis is one of the major strategies. Therefore, the aim of this study was to evaluate the utilization of post-exposure prophylaxis (PEP) among victims of HIV at the University of Gondar Comprehensive Specialized Hospital, north-west Ethiopia. A retrospective cross-sectional study was conducted from May 17, 2018, to May 24, 2018 and descriptive statistics were carried out to analyze the Data using SPSS version 20.Results: From a total of 309 patients PEP was prescribed during the study period, of whom 239 (77.34%) were occupational victims and 55 (17.8%) were rape victims, with one missing data. Occupational victims were exposed by blood and blood product splashes and nurses and physicians were exposed almost equally, 14.24% and 13.92%, respectively. The majority of the victims were exposed at a health facility. Two hundred and eighty-five (92.23%) victims received prescriptions containing three-drug regimens, tenofovir + lamivudine + efavirenz, followed by 9 victims (2.91%) with two-drug regimens; zidovudine + lamivudine. There are no follow-up mechanisms as a result the completion rate and the outcome of PEP was not determined.Conclusion: PEP was initiated within 72 hr, most within 24 hr. The adherence was unknown with poor follow-up despite the strong recommendations of the national and WHO guidelines.Keywords: PEP, PEP utilization, nPEP, HIV, healthcare workers, University of Gondar Comprehensive Specialized Hospital
format	article
author	Temesgen E Weldu H Ayalew Getahun K Jemere Aragaw T
author_facet	Temesgen E Weldu H Ayalew Getahun K Jemere Aragaw T
author_sort	Temesgen E
title	Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia
title_short	Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia
title_full	Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia
title_fullStr	Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia
title_full_unstemmed	Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia
title_sort	evaluation of post-exposure prophylaxis utilization among human immunodeficiency virus exposed victims at university of gondar comprehensive specialized hospital, north west ethiopia
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/48a559636970484bb04c5035e2203251
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Evaluation of Post-Exposure Prophylaxis Utilization Among Human Immunodeficiency Virus Exposed Victims at University of Gondar Comprehensive Specialized Hospital, North West Ethiopia

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