Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study

Human Immunodeficiency Virus (HIV) infected children have a 30–70% chance of being incompletely immunized and may not respond serologically with the same magnitude or durability as uninfected children. The aim of the study was to describe the rate of protective antibodies titre and the persistence o...

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Autores principales:	Eugenia Bruzzese, Federica Pagano, Alfredo Diana, Liana Punzi, Alfredo Guarino
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HIV infection vaccines immune response children Medicine R
Acceso en línea:	https://doaj.org/article/48a70f59886240bca550b3d5a313b3f2
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spelling	oai:doaj.org-article:48a70f59886240bca550b3d5a313b3f22021-11-25T19:11:23ZProtection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study10.3390/vaccines91113312076-393Xhttps://doaj.org/article/48a70f59886240bca550b3d5a313b3f22021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1331https://doaj.org/toc/2076-393XHuman Immunodeficiency Virus (HIV) infected children have a 30–70% chance of being incompletely immunized and may not respond serologically with the same magnitude or durability as uninfected children. The aim of the study was to describe the rate of protective antibodies titre and the persistence of the response against four recommended vaccinations in HIV infected children and adolescents. A two-phase observational study was performed in which protective IgG antibodies to measles, mumps, rubella and hepatitis B were determined and monitored for 12 and 24 months, in 26 perinatally HIV-infected children. The rate of protection for rubella and hepatitis B was significantly lower in the HIV group compared to the control group (92% vs. 65% for rubella and 78.4% vs. 45.4% for hepatitis B; <i>p</i> < 0.05). Children who received primary vaccination after initiating combination antiretroviral therapy (cART) had a higher rate of response. Seronegative patients who received a booster dose of vaccine had a good immunological response. HIV infection is associated with a lower response to vaccines against rubella and hepatitis. The beginning of cART before vaccination may be associated with a better response. The evaluation of the serological response is crucial in children with HIV infection in order to evaluate the protection of vaccine preventable diseases.Eugenia BruzzeseFederica PaganoAlfredo DianaLiana PunziAlfredo GuarinoMDPI AGarticleHIV infectionvaccinesimmune responsechildrenMedicineRENVaccines, Vol 9, Iss 1331, p 1331 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HIV infection vaccines immune response children Medicine R
spellingShingle	HIV infection vaccines immune response children Medicine R Eugenia Bruzzese Federica Pagano Alfredo Diana Liana Punzi Alfredo Guarino Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study
description	Human Immunodeficiency Virus (HIV) infected children have a 30–70% chance of being incompletely immunized and may not respond serologically with the same magnitude or durability as uninfected children. The aim of the study was to describe the rate of protective antibodies titre and the persistence of the response against four recommended vaccinations in HIV infected children and adolescents. A two-phase observational study was performed in which protective IgG antibodies to measles, mumps, rubella and hepatitis B were determined and monitored for 12 and 24 months, in 26 perinatally HIV-infected children. The rate of protection for rubella and hepatitis B was significantly lower in the HIV group compared to the control group (92% vs. 65% for rubella and 78.4% vs. 45.4% for hepatitis B; <i>p</i> < 0.05). Children who received primary vaccination after initiating combination antiretroviral therapy (cART) had a higher rate of response. Seronegative patients who received a booster dose of vaccine had a good immunological response. HIV infection is associated with a lower response to vaccines against rubella and hepatitis. The beginning of cART before vaccination may be associated with a better response. The evaluation of the serological response is crucial in children with HIV infection in order to evaluate the protection of vaccine preventable diseases.
format	article
author	Eugenia Bruzzese Federica Pagano Alfredo Diana Liana Punzi Alfredo Guarino
author_facet	Eugenia Bruzzese Federica Pagano Alfredo Diana Liana Punzi Alfredo Guarino
author_sort	Eugenia Bruzzese
title	Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study
title_short	Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study
title_full	Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study
title_fullStr	Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study
title_full_unstemmed	Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study
title_sort	protection of vaccine preventable diseases in a population of hiv-infected children: a 3 years prospective study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48a70f59886240bca550b3d5a313b3f2
work_keys_str_mv	AT eugeniabruzzese protectionofvaccinepreventablediseasesinapopulationofhivinfectedchildrena3yearsprospectivestudy AT federicapagano protectionofvaccinepreventablediseasesinapopulationofhivinfectedchildrena3yearsprospectivestudy AT alfredodiana protectionofvaccinepreventablediseasesinapopulationofhivinfectedchildrena3yearsprospectivestudy AT lianapunzi protectionofvaccinepreventablediseasesinapopulationofhivinfectedchildrena3yearsprospectivestudy AT alfredoguarino protectionofvaccinepreventablediseasesinapopulationofhivinfectedchildrena3yearsprospectivestudy
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Protection of Vaccine Preventable Diseases in a Population of HIV-Infected Children: A 3 Years Prospective Study

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