Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study

Background: Sentinel lymph node biopsy (SLNB), as a common method for axillary staging of early breast cancer, has gradually attracted people’s attention to the false-negative rate and postoperative complications. The aim of the study is to investigate the clinical value of preoperative contrast-enh...

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Autores principales:	Yangyang Zhu, Xiao Fan, Dan Yang, Tiantian Dong, Yingying Jia, Fang Nie
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer contrast agents sentinel lymph node ultrasonography Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/48a7ccb37b8b4ea4b2b328b9eda89efa
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spelling	oai:doaj.org-article:48a7ccb37b8b4ea4b2b328b9eda89efa2021-11-25T17:21:40ZContrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study10.3390/diagnostics111121042075-4418https://doaj.org/article/48a7ccb37b8b4ea4b2b328b9eda89efa2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2104https://doaj.org/toc/2075-4418Background: Sentinel lymph node biopsy (SLNB), as a common method for axillary staging of early breast cancer, has gradually attracted people’s attention to the false-negative rate and postoperative complications. The aim of the study is to investigate the clinical value of preoperative contrast-enhanced ultrasound (CEUS) for intraoperative SLNB in early breast cancer patients. Methods: A total of 201 patients scheduled for SLNB from September 2018 to April 2021 were collected consecutively. Preoperative CEUS was used to identify sentinel lymph nodes (SLN) and lymphatic drainage in breast cancer patients. Results: The SLN identification rate of CEUS was 93.0% (187/201) and four lymphatic drainage patterns were found: single LC to single SLN (70.0%), multiple LCs to single SLN (8.0%), single LC to multiple SLNs (10.2%), and multiple LCs to multiple SLNs (11.8%). The Sen, Spe, PPV, NPV, AUC of CEUS, US and CEUS + US in diagnosis of SLNs were 82.7%, 80.4%, 73.8%, 87.4%, 0.815; 70.7%, 77.7%, 68.0%, 79.8%, 0.742; and 86.7%, 77.7%, 72.2%, 89.7%, 0.822, respectively. There was no statistically significant difference between the diagnostic performance of CEUS and CEUS + US (<i>p</i> = 0.630). Conclusions: CEUS can be used to preoperatively assess the lymphatic drainage patterns and the status of the SLNs in early breast cancer to assist precision intraoperative SLNB.Yangyang ZhuXiao FanDan YangTiantian DongYingying JiaFang NieMDPI AGarticlebreast cancercontrast agentssentinel lymph nodeultrasonographyMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2104, p 2104 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer contrast agents sentinel lymph node ultrasonography Medicine (General) R5-920
spellingShingle	breast cancer contrast agents sentinel lymph node ultrasonography Medicine (General) R5-920 Yangyang Zhu Xiao Fan Dan Yang Tiantian Dong Yingying Jia Fang Nie Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study
description	Background: Sentinel lymph node biopsy (SLNB), as a common method for axillary staging of early breast cancer, has gradually attracted people’s attention to the false-negative rate and postoperative complications. The aim of the study is to investigate the clinical value of preoperative contrast-enhanced ultrasound (CEUS) for intraoperative SLNB in early breast cancer patients. Methods: A total of 201 patients scheduled for SLNB from September 2018 to April 2021 were collected consecutively. Preoperative CEUS was used to identify sentinel lymph nodes (SLN) and lymphatic drainage in breast cancer patients. Results: The SLN identification rate of CEUS was 93.0% (187/201) and four lymphatic drainage patterns were found: single LC to single SLN (70.0%), multiple LCs to single SLN (8.0%), single LC to multiple SLNs (10.2%), and multiple LCs to multiple SLNs (11.8%). The Sen, Spe, PPV, NPV, AUC of CEUS, US and CEUS + US in diagnosis of SLNs were 82.7%, 80.4%, 73.8%, 87.4%, 0.815; 70.7%, 77.7%, 68.0%, 79.8%, 0.742; and 86.7%, 77.7%, 72.2%, 89.7%, 0.822, respectively. There was no statistically significant difference between the diagnostic performance of CEUS and CEUS + US (<i>p</i> = 0.630). Conclusions: CEUS can be used to preoperatively assess the lymphatic drainage patterns and the status of the SLNs in early breast cancer to assist precision intraoperative SLNB.
format	article
author	Yangyang Zhu Xiao Fan Dan Yang Tiantian Dong Yingying Jia Fang Nie
author_facet	Yangyang Zhu Xiao Fan Dan Yang Tiantian Dong Yingying Jia Fang Nie
author_sort	Yangyang Zhu
title	Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study
title_short	Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study
title_full	Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study
title_fullStr	Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study
title_full_unstemmed	Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study
title_sort	contrast-enhanced ultrasound for precise sentinel lymph node biopsy in women with early breast cancer: a preliminary study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48a7ccb37b8b4ea4b2b328b9eda89efa
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Contrast-Enhanced Ultrasound for Precise Sentinel Lymph Node Biopsy in Women with Early Breast Cancer: A Preliminary Study

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