A novel role for minimal introns: routing mRNAs to the cytosol.
<h4>Background</h4>Introns and their splicing are tightly coupled with the subsequent mRNA maturation steps, especially nucleocytoplasmic export. A remarkable fraction of vertebrate introns have a minimal size of about 100 bp, while majority of introns expand to several kilobases even me...
Guardado en:
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2010
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/48aa5cc4ae954fddb86f9398912a837f |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:48aa5cc4ae954fddb86f9398912a837f |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:48aa5cc4ae954fddb86f9398912a837f2021-11-25T06:24:36ZA novel role for minimal introns: routing mRNAs to the cytosol.1932-620310.1371/journal.pone.0010144https://doaj.org/article/48aa5cc4ae954fddb86f9398912a837f2010-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20419085/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Introns and their splicing are tightly coupled with the subsequent mRNA maturation steps, especially nucleocytoplasmic export. A remarkable fraction of vertebrate introns have a minimal size of about 100 bp, while majority of introns expand to several kilobases even megabases in length.<h4>Principal findings</h4>We carried out analyses on the evolution and function of minimal introns (50-150 bp) in human and mouse genomes. We found that minimal introns are conserved in terms of both length and sequence. They are preferentially located toward 3' end of mRNA and non-randomly distributed among chromosomes. Both the evolutionary conservation and non-random distribution are indicative of biological relevance. We showed that genes with minimal introns have higher abundance, larger size, and tend to be universally expressed as compared to genes with only large introns and intron-less genes. Genes with minimal introns replicate earlier and preferentially reside in the vicinities of open chromatin, suggesting their unique nuclear position and potential relevance to the regulation of gene expression and transcript export.<h4>Conclusions</h4>Based on these observations, we proposed a nuclear-export routing model, where minimal introns play a regulatory role in selectively exporting the highly abundant and large housekeeping genes that reside at the surface of chromatin territories, and thus preventing entanglement with other genes located at the interior locations.Jiang ZhuFuhong HeDapeng WangKan LiuDawei HuangJingfa XiaoJiayan WuSongnian HuJun YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 4, p e10144 (2010) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Jiang Zhu Fuhong He Dapeng Wang Kan Liu Dawei Huang Jingfa Xiao Jiayan Wu Songnian Hu Jun Yu A novel role for minimal introns: routing mRNAs to the cytosol. |
| description |
<h4>Background</h4>Introns and their splicing are tightly coupled with the subsequent mRNA maturation steps, especially nucleocytoplasmic export. A remarkable fraction of vertebrate introns have a minimal size of about 100 bp, while majority of introns expand to several kilobases even megabases in length.<h4>Principal findings</h4>We carried out analyses on the evolution and function of minimal introns (50-150 bp) in human and mouse genomes. We found that minimal introns are conserved in terms of both length and sequence. They are preferentially located toward 3' end of mRNA and non-randomly distributed among chromosomes. Both the evolutionary conservation and non-random distribution are indicative of biological relevance. We showed that genes with minimal introns have higher abundance, larger size, and tend to be universally expressed as compared to genes with only large introns and intron-less genes. Genes with minimal introns replicate earlier and preferentially reside in the vicinities of open chromatin, suggesting their unique nuclear position and potential relevance to the regulation of gene expression and transcript export.<h4>Conclusions</h4>Based on these observations, we proposed a nuclear-export routing model, where minimal introns play a regulatory role in selectively exporting the highly abundant and large housekeeping genes that reside at the surface of chromatin territories, and thus preventing entanglement with other genes located at the interior locations. |
| format |
article |
| author |
Jiang Zhu Fuhong He Dapeng Wang Kan Liu Dawei Huang Jingfa Xiao Jiayan Wu Songnian Hu Jun Yu |
| author_facet |
Jiang Zhu Fuhong He Dapeng Wang Kan Liu Dawei Huang Jingfa Xiao Jiayan Wu Songnian Hu Jun Yu |
| author_sort |
Jiang Zhu |
| title |
A novel role for minimal introns: routing mRNAs to the cytosol. |
| title_short |
A novel role for minimal introns: routing mRNAs to the cytosol. |
| title_full |
A novel role for minimal introns: routing mRNAs to the cytosol. |
| title_fullStr |
A novel role for minimal introns: routing mRNAs to the cytosol. |
| title_full_unstemmed |
A novel role for minimal introns: routing mRNAs to the cytosol. |
| title_sort |
novel role for minimal introns: routing mrnas to the cytosol. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2010 |
| url |
https://doaj.org/article/48aa5cc4ae954fddb86f9398912a837f |
| work_keys_str_mv |
AT jiangzhu anovelroleforminimalintronsroutingmrnastothecytosol AT fuhonghe anovelroleforminimalintronsroutingmrnastothecytosol AT dapengwang anovelroleforminimalintronsroutingmrnastothecytosol AT kanliu anovelroleforminimalintronsroutingmrnastothecytosol AT daweihuang anovelroleforminimalintronsroutingmrnastothecytosol AT jingfaxiao anovelroleforminimalintronsroutingmrnastothecytosol AT jiayanwu anovelroleforminimalintronsroutingmrnastothecytosol AT songnianhu anovelroleforminimalintronsroutingmrnastothecytosol AT junyu anovelroleforminimalintronsroutingmrnastothecytosol AT jiangzhu novelroleforminimalintronsroutingmrnastothecytosol AT fuhonghe novelroleforminimalintronsroutingmrnastothecytosol AT dapengwang novelroleforminimalintronsroutingmrnastothecytosol AT kanliu novelroleforminimalintronsroutingmrnastothecytosol AT daweihuang novelroleforminimalintronsroutingmrnastothecytosol AT jingfaxiao novelroleforminimalintronsroutingmrnastothecytosol AT jiayanwu novelroleforminimalintronsroutingmrnastothecytosol AT songnianhu novelroleforminimalintronsroutingmrnastothecytosol AT junyu novelroleforminimalintronsroutingmrnastothecytosol |
| _version_ |
1718413740282478592 |