Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants

AbstractIntroduction: In spite of significant advances in medical care, neonatal sepsis remains an important risk factor for neonatal morbidity and mortality. Accordingly, the present study was conducted to compare the number of Nucleated Red Blood Cells per 100 white blood cells (NRBC/100WBC) in ne...

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Autores principales:	Hassan Boskabadi, Mohammad Hadi Sadeghian, Baratali Meshkani, Maryam Zakerihamidi
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2019
Materias:	Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/48c10c24f6f349a78c1928160eecf8d9
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spelling	oai:doaj.org-article:48c10c24f6f349a78c1928160eecf8d92021-11-22T07:09:56ZComparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants2220-76192313-7398https://doaj.org/article/48c10c24f6f349a78c1928160eecf8d92019-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1588https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398AbstractIntroduction: In spite of significant advances in medical care, neonatal sepsis remains an important risk factor for neonatal morbidity and mortality. Accordingly, the present study was conducted to compare the number of Nucleated Red Blood Cells per 100 white blood cells (NRBC/100WBC) in neonates with early onset sepsis and non-infectious neonates.Materials and Methods: In this cross-sectional study, of 154 neonates admitted to the NICU of Ghaem Hospital in Mashhad, Iran within the first three days of life, during 2014 to 2018, the characteristics of 44 neonates identified early onset sepsis (Case group) were compared with 110 non-infectious neonates (Control group). After the confirmation of sepsis in neonates based on positive blood culture and laboratory results, a researcher-made questionnaire containing neonatal characteristics (gestational age, weight, first minute Apgar scores, fifth minute Apgar score, duration of oxygen therapy, and mechanical ventilation duration) and neonatal laboratory profiles (Cord blood samples CBC (complete blood count), Absolut NRBC/mm3, NRBC/100 WBC and CRP) was filled in.Results: The results of this study showed that the absolute number of NRBC/mm3 in control group was 56.07±86.65and in case group was 592.70±1166.75 (p = 0.000). Also, the number of NRBC per 100 white blood cells in control group was 6.54±11.18and in case group was 31.84±40.07 (p = 0.000). The absolute number of NRBC/mm3 for the detection of early onset sepsis had a good sensitivity (78%) and NRBC/100WBC was suitable specificity (68.2%).Conclusion: This study indicated that NRBC/100 WBC and absolute NRBC count/mm3 can be helpful in the diagnosis of early onset sepsis and have an acceptable sensitivity and specificity.Keywords: Early onset Sepsis; Nucleated Red Blood Cells [NRBC]; Neonates, Blood cultureHassan BoskabadiMohammad Hadi SadeghianBaratali MeshkaniMaryam ZakerihamidiSankt-Peterburg : NIIÈM imeni PasteraarticleInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 0, Iss 0 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	Infectious and parasitic diseases RC109-216
spellingShingle	Infectious and parasitic diseases RC109-216 Hassan Boskabadi Mohammad Hadi Sadeghian Baratali Meshkani Maryam Zakerihamidi Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants
description	AbstractIntroduction: In spite of significant advances in medical care, neonatal sepsis remains an important risk factor for neonatal morbidity and mortality. Accordingly, the present study was conducted to compare the number of Nucleated Red Blood Cells per 100 white blood cells (NRBC/100WBC) in neonates with early onset sepsis and non-infectious neonates.Materials and Methods: In this cross-sectional study, of 154 neonates admitted to the NICU of Ghaem Hospital in Mashhad, Iran within the first three days of life, during 2014 to 2018, the characteristics of 44 neonates identified early onset sepsis (Case group) were compared with 110 non-infectious neonates (Control group). After the confirmation of sepsis in neonates based on positive blood culture and laboratory results, a researcher-made questionnaire containing neonatal characteristics (gestational age, weight, first minute Apgar scores, fifth minute Apgar score, duration of oxygen therapy, and mechanical ventilation duration) and neonatal laboratory profiles (Cord blood samples CBC (complete blood count), Absolut NRBC/mm3, NRBC/100 WBC and CRP) was filled in.Results: The results of this study showed that the absolute number of NRBC/mm3 in control group was 56.07±86.65and in case group was 592.70±1166.75 (p = 0.000). Also, the number of NRBC per 100 white blood cells in control group was 6.54±11.18and in case group was 31.84±40.07 (p = 0.000). The absolute number of NRBC/mm3 for the detection of early onset sepsis had a good sensitivity (78%) and NRBC/100WBC was suitable specificity (68.2%).Conclusion: This study indicated that NRBC/100 WBC and absolute NRBC count/mm3 can be helpful in the diagnosis of early onset sepsis and have an acceptable sensitivity and specificity.Keywords: Early onset Sepsis; Nucleated Red Blood Cells [NRBC]; Neonates, Blood culture
format	article
author	Hassan Boskabadi Mohammad Hadi Sadeghian Baratali Meshkani Maryam Zakerihamidi
author_facet	Hassan Boskabadi Mohammad Hadi Sadeghian Baratali Meshkani Maryam Zakerihamidi
author_sort	Hassan Boskabadi
title	Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants
title_short	Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants
title_full	Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants
title_fullStr	Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants
title_full_unstemmed	Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants
title_sort	comparison of the percentage of nrbc/100 wbc in early onset sepsis and non-infectious premature infants
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2019
url	https://doaj.org/article/48c10c24f6f349a78c1928160eecf8d9
work_keys_str_mv	AT hassanboskabadi comparisonofthepercentageofnrbc100wbcinearlyonsetsepsisandnoninfectiousprematureinfants AT mohammadhadisadeghian comparisonofthepercentageofnrbc100wbcinearlyonsetsepsisandnoninfectiousprematureinfants AT baratalimeshkani comparisonofthepercentageofnrbc100wbcinearlyonsetsepsisandnoninfectiousprematureinfants AT maryamzakerihamidi comparisonofthepercentageofnrbc100wbcinearlyonsetsepsisandnoninfectiousprematureinfants
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Comparison of the percentage of NRBC/100 WBC in early onset sepsis and Non-Infectious premature infants

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