Activity-independent targeting of mTOR to lysosomes in primary osteoclasts

Activity-independent targeting of mTOR to lysosomes in primary osteoclasts

Abstract Mammalian target of rapamycin (mTOR) is activated by numerous stimuli, including amino acids and growth factors. This kinase is part of the mTOR complex 1 (mTORC1) which regulates cell proliferation, differentiation, and autophagy. Active mTORC1 is located on lysosomes and has been reported...

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Autores principales: Andrew Wang, Luciene R. Carraro-Lacroix, Celeste Owen, Bowen Gao, Paul N. Corey, Pascal Tyrrell, John H. Brumell, Irina Voronov
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/48c316c68a3b41edb20300c3142b91c4
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