Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps

Abstract The previously more frequently implanted pulsatile blood pumps (PBPs) showed higher recovery rates than the currently preferred rotary blood pumps (RBPs), with unclear causality. The aim of this study was to comparatively assess the capability of PBPs and RPBs to unload the left ventricle a...

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Autores principales:	Marcus Granegger, Young Choi, Benedikt Locher, Philipp Aigner, Emanuel J. Hubmann, Frithjof Lemme, Nikola Cesarovic, Michael Hübler, Martin Schweiger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48c49f4403f747b1ab11cf52f7e58a59
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spelling	oai:doaj.org-article:48c49f4403f747b1ab11cf52f7e58a592021-12-02T13:35:11ZComparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps10.1038/s41598-019-56344-82045-2322https://doaj.org/article/48c49f4403f747b1ab11cf52f7e58a592019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56344-8https://doaj.org/toc/2045-2322Abstract The previously more frequently implanted pulsatile blood pumps (PBPs) showed higher recovery rates than the currently preferred rotary blood pumps (RBPs), with unclear causality. The aim of this study was to comparatively assess the capability of PBPs and RPBs to unload the left ventricle and maintain cardiac energetics as a possible implication for recovery. An RBP and a heartbeat synchronized PBP were alternately connected to isolated porcine hearts. Rotational speed of RBPs was set to different support levels. For PBP support, the start of ejection was phased to different points during the cardiac cycle, prescribed as percentage delays from 0% to 90%. Cardiac efficiency, quantified by the ratio of external work over myocardial oxygen consumption, was determined. For RBP support, higher degrees of RBP support correlated with lower left atrial pressures (LAP) and lower cardiac efficiency (r = 0.91 ± 0.12). In contrast, depending on the phase delay of a PBP, LAP and cardiac efficiency exhibited a sinusoidal relationship with the LAP minimum at 90% and efficiency maximum at 60%. Phasing of a PBP offers the possibility to maintain a high cardiac efficiency and simultaneously unload the ventricle. These results warrant future studies investigating whether optimized cardiac energetics promotes functional recovery with LVAD therapy.Marcus GraneggerYoung ChoiBenedikt LocherPhilipp AignerEmanuel J. HubmannFrithjof LemmeNikola CesarovicMichael HüblerMartin SchweigerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marcus Granegger Young Choi Benedikt Locher Philipp Aigner Emanuel J. Hubmann Frithjof Lemme Nikola Cesarovic Michael Hübler Martin Schweiger Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
description	Abstract The previously more frequently implanted pulsatile blood pumps (PBPs) showed higher recovery rates than the currently preferred rotary blood pumps (RBPs), with unclear causality. The aim of this study was to comparatively assess the capability of PBPs and RPBs to unload the left ventricle and maintain cardiac energetics as a possible implication for recovery. An RBP and a heartbeat synchronized PBP were alternately connected to isolated porcine hearts. Rotational speed of RBPs was set to different support levels. For PBP support, the start of ejection was phased to different points during the cardiac cycle, prescribed as percentage delays from 0% to 90%. Cardiac efficiency, quantified by the ratio of external work over myocardial oxygen consumption, was determined. For RBP support, higher degrees of RBP support correlated with lower left atrial pressures (LAP) and lower cardiac efficiency (r = 0.91 ± 0.12). In contrast, depending on the phase delay of a PBP, LAP and cardiac efficiency exhibited a sinusoidal relationship with the LAP minimum at 90% and efficiency maximum at 60%. Phasing of a PBP offers the possibility to maintain a high cardiac efficiency and simultaneously unload the ventricle. These results warrant future studies investigating whether optimized cardiac energetics promotes functional recovery with LVAD therapy.
format	article
author	Marcus Granegger Young Choi Benedikt Locher Philipp Aigner Emanuel J. Hubmann Frithjof Lemme Nikola Cesarovic Michael Hübler Martin Schweiger
author_facet	Marcus Granegger Young Choi Benedikt Locher Philipp Aigner Emanuel J. Hubmann Frithjof Lemme Nikola Cesarovic Michael Hübler Martin Schweiger
author_sort	Marcus Granegger
title	Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
title_short	Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
title_full	Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
title_fullStr	Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
title_full_unstemmed	Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
title_sort	comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/48c49f4403f747b1ab11cf52f7e58a59
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Comparative analysis of cardiac mechano-energetics in isolated hearts supported by pulsatile or rotary blood pumps

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