Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane

This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chit...

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Autores principales:	Khabibi Khabibi, Dwi Siswanta, Mudasir Mudasir
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2021
Materias:	chitosan cmc membrane hemodialysis Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/48c4d0b448b44caf8e2727216441cd8e
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spelling	oai:doaj.org-article:48c4d0b448b44caf8e2727216441cd8e2021-12-02T18:02:39ZPreparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane1411-94202460-157810.22146/ijc.61704https://doaj.org/article/48c4d0b448b44caf8e2727216441cd8e2021-09-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/61704https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chitosan was crosslinked with glutaraldehyde in various monomers ratios, and the membranes formed were characterized by FTIR, SEM, and TGA. Furthermore, the hydrophilicity, swelling, porosity, mechanical strength, and dialysis performance of the membranes against urea and creatinine were systematically examined, and their in-vitro hemocompatibility tests were also conducted. The results showed that the CS/CMC-GA membranes have higher hydrophilicity, swelling, porosity, mechanical strength, and better dialysis performance against urea and creatinine than chitosan without modification. In addition, the hemocompatibility test indicated that the CS/CMC-GA membranes have lower values of protein adsorption, thrombocyte attachment, hemolysis ratio, and partial thromboplastin time (PTT) than that of pristine chitosan. Based on these results, the CC/CMC-GA membranes have better hemocompatibility and the potential to be used as hemodialysis membranes.Khabibi KhabibiDwi SiswantaMudasir MudasirDepartment of Chemistry, Universitas Gadjah MadaarticlechitosancmcmembranehemodialysisChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 5, Pp 1120-1131 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan cmc membrane hemodialysis Chemistry QD1-999
spellingShingle	chitosan cmc membrane hemodialysis Chemistry QD1-999 Khabibi Khabibi Dwi Siswanta Mudasir Mudasir Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane
description	This study aims to examine the manufacture, characterization, and in vitro hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethyl cellulose (CS/CMC-GA) as a hemodialysis membrane. The CS/CMC-GA membrane was prepared using the phase inversion method with 1.5% CS and 0.1% CMC. The chitosan was crosslinked with glutaraldehyde in various monomers ratios, and the membranes formed were characterized by FTIR, SEM, and TGA. Furthermore, the hydrophilicity, swelling, porosity, mechanical strength, and dialysis performance of the membranes against urea and creatinine were systematically examined, and their in-vitro hemocompatibility tests were also conducted. The results showed that the CS/CMC-GA membranes have higher hydrophilicity, swelling, porosity, mechanical strength, and better dialysis performance against urea and creatinine than chitosan without modification. In addition, the hemocompatibility test indicated that the CS/CMC-GA membranes have lower values of protein adsorption, thrombocyte attachment, hemolysis ratio, and partial thromboplastin time (PTT) than that of pristine chitosan. Based on these results, the CC/CMC-GA membranes have better hemocompatibility and the potential to be used as hemodialysis membranes.
format	article
author	Khabibi Khabibi Dwi Siswanta Mudasir Mudasir
author_facet	Khabibi Khabibi Dwi Siswanta Mudasir Mudasir
author_sort	Khabibi Khabibi
title	Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane
title_short	Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane
title_full	Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane
title_fullStr	Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane
title_full_unstemmed	Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane
title_sort	preparation, characterization, and <i>in vitro</i> hemocompatibility of glutaraldehyde-crosslinked chitosan/carboxymethylcellulose as hemodialysis membrane
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/48c4d0b448b44caf8e2727216441cd8e
work_keys_str_mv	AT khabibikhabibi preparationcharacterizationandiinvitroihemocompatibilityofglutaraldehydecrosslinkedchitosancarboxymethylcelluloseashemodialysismembrane AT dwisiswanta preparationcharacterizationandiinvitroihemocompatibilityofglutaraldehydecrosslinkedchitosancarboxymethylcelluloseashemodialysismembrane AT mudasirmudasir preparationcharacterizationandiinvitroihemocompatibilityofglutaraldehydecrosslinkedchitosancarboxymethylcelluloseashemodialysismembrane
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Preparation, Characterization, and <i>In Vitro</i> Hemocompatibility of Glutaraldehyde-Crosslinked Chitosan/Carboxymethylcellulose as Hemodialysis Membrane

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