Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and dysregulation of this process leads to ataxia and other diseases. Here the authors show that the LIM-homeodomain transcription factors Lhx1 and Lhx5 govern dendritogenesis and dendritic spine...

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Autores principales:	Nga Chu Lui, Wing Yip Tam, Caiji Gao, Jian-Dong Huang, Chi Chiu Wang, Liwen Jiang, Wing Ho Yung, Kin Ming Kwan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48c6986ca9f3427294ec05c869483932
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id	oai:doaj.org-article:48c6986ca9f3427294ec05c869483932
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spelling	oai:doaj.org-article:48c6986ca9f3427294ec05c8694839322021-12-02T15:38:58ZLhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin10.1038/ncomms150792041-1723https://doaj.org/article/48c6986ca9f3427294ec05c8694839322017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15079https://doaj.org/toc/2041-1723Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and dysregulation of this process leads to ataxia and other diseases. Here the authors show that the LIM-homeodomain transcription factors Lhx1 and Lhx5 govern dendritogenesis and dendritic spine morphogenesis in postnatal PCs through regulating Espin expression.Nga Chu LuiWing Yip TamCaiji GaoJian-Dong HuangChi Chiu WangLiwen JiangWing Ho YungKin Ming KwanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nga Chu Lui Wing Yip Tam Caiji Gao Jian-Dong Huang Chi Chiu Wang Liwen Jiang Wing Ho Yung Kin Ming Kwan Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin
description	Purkinje cells (PCs) receive signals from different inputs through their extensively branched dendrites and dysregulation of this process leads to ataxia and other diseases. Here the authors show that the LIM-homeodomain transcription factors Lhx1 and Lhx5 govern dendritogenesis and dendritic spine morphogenesis in postnatal PCs through regulating Espin expression.
format	article
author	Nga Chu Lui Wing Yip Tam Caiji Gao Jian-Dong Huang Chi Chiu Wang Liwen Jiang Wing Ho Yung Kin Ming Kwan
author_facet	Nga Chu Lui Wing Yip Tam Caiji Gao Jian-Dong Huang Chi Chiu Wang Liwen Jiang Wing Ho Yung Kin Ming Kwan
author_sort	Nga Chu Lui
title	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin
title_short	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin
title_full	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin
title_fullStr	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin
title_full_unstemmed	Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin
title_sort	lhx1/5 control dendritogenesis and spine morphogenesis of purkinje cells via regulation of espin
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/48c6986ca9f3427294ec05c869483932
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Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin

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