Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.

Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.

In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat s...

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Autores principales: Jonathan S Towner, Brian R Amman, Tara K Sealy, Serena A Reeder Carroll, James A Comer, Alan Kemp, Robert Swanepoel, Christopher D Paddock, Stephen Balinandi, Marina L Khristova, Pierre B H Formenty, Cesar G Albarino, David M Miller, Zachary D Reed, John T Kayiwa, James N Mills, Deborah L Cannon, Patricia W Greer, Emmanuel Byaruhanga, Eileen C Farnon, Patrick Atimnedi, Samuel Okware, Edward Katongole-Mbidde, Robert Downing, Jordan W Tappero, Sherif R Zaki, Thomas G Ksiazek, Stuart T Nichol, Pierre E Rollin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
Materias:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/48c76fd0d0f24675a8685e80939b4f49
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Sumario:In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat sera, and isolation of genetically diverse virus from bat tissues. The virus isolates were collected nine months apart, demonstrating long-term virus circulation. The bat colony was estimated to be over 100,000 animals using mark and re-capture methods, predicting the presence of over 5,000 virus-infected bats. The genetically diverse virus genome sequences from bats and miners closely matched. These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans.

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