Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.

In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat s...

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Autores principales:	Jonathan S Towner, Brian R Amman, Tara K Sealy, Serena A Reeder Carroll, James A Comer, Alan Kemp, Robert Swanepoel, Christopher D Paddock, Stephen Balinandi, Marina L Khristova, Pierre B H Formenty, Cesar G Albarino, David M Miller, Zachary D Reed, John T Kayiwa, James N Mills, Deborah L Cannon, Patricia W Greer, Emmanuel Byaruhanga, Eileen C Farnon, Patrick Atimnedi, Samuel Okware, Edward Katongole-Mbidde, Robert Downing, Jordan W Tappero, Sherif R Zaki, Thomas G Ksiazek, Stuart T Nichol, Pierre E Rollin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/48c76fd0d0f24675a8685e80939b4f49
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spelling	oai:doaj.org-article:48c76fd0d0f24675a8685e80939b4f492021-11-25T05:47:44ZIsolation of genetically diverse Marburg viruses from Egyptian fruit bats.1553-73661553-737410.1371/journal.ppat.1000536https://doaj.org/article/48c76fd0d0f24675a8685e80939b4f492009-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19649327/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat sera, and isolation of genetically diverse virus from bat tissues. The virus isolates were collected nine months apart, demonstrating long-term virus circulation. The bat colony was estimated to be over 100,000 animals using mark and re-capture methods, predicting the presence of over 5,000 virus-infected bats. The genetically diverse virus genome sequences from bats and miners closely matched. These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans.Jonathan S TownerBrian R AmmanTara K SealySerena A Reeder CarrollJames A ComerAlan KempRobert SwanepoelChristopher D PaddockStephen BalinandiMarina L KhristovaPierre B H FormentyCesar G AlbarinoDavid M MillerZachary D ReedJohn T KayiwaJames N MillsDeborah L CannonPatricia W GreerEmmanuel ByaruhangaEileen C FarnonPatrick AtimnediSamuel OkwareEdward Katongole-MbiddeRobert DowningJordan W TapperoSherif R ZakiThomas G KsiazekStuart T NicholPierre E RollinPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 5, Iss 7, p e1000536 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Jonathan S Towner Brian R Amman Tara K Sealy Serena A Reeder Carroll James A Comer Alan Kemp Robert Swanepoel Christopher D Paddock Stephen Balinandi Marina L Khristova Pierre B H Formenty Cesar G Albarino David M Miller Zachary D Reed John T Kayiwa James N Mills Deborah L Cannon Patricia W Greer Emmanuel Byaruhanga Eileen C Farnon Patrick Atimnedi Samuel Okware Edward Katongole-Mbidde Robert Downing Jordan W Tappero Sherif R Zaki Thomas G Ksiazek Stuart T Nichol Pierre E Rollin Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
description	In July and September 2007, miners working in Kitaka Cave, Uganda, were diagnosed with Marburg hemorrhagic fever. The likely source of infection in the cave was Egyptian fruit bats (Rousettus aegyptiacus) based on detection of Marburg virus RNA in 31/611 (5.1%) bats, virus-specific antibody in bat sera, and isolation of genetically diverse virus from bat tissues. The virus isolates were collected nine months apart, demonstrating long-term virus circulation. The bat colony was estimated to be over 100,000 animals using mark and re-capture methods, predicting the presence of over 5,000 virus-infected bats. The genetically diverse virus genome sequences from bats and miners closely matched. These data indicate common Egyptian fruit bats can represent a major natural reservoir and source of Marburg virus with potential for spillover into humans.
format	article
author	Jonathan S Towner Brian R Amman Tara K Sealy Serena A Reeder Carroll James A Comer Alan Kemp Robert Swanepoel Christopher D Paddock Stephen Balinandi Marina L Khristova Pierre B H Formenty Cesar G Albarino David M Miller Zachary D Reed John T Kayiwa James N Mills Deborah L Cannon Patricia W Greer Emmanuel Byaruhanga Eileen C Farnon Patrick Atimnedi Samuel Okware Edward Katongole-Mbidde Robert Downing Jordan W Tappero Sherif R Zaki Thomas G Ksiazek Stuart T Nichol Pierre E Rollin
author_facet	Jonathan S Towner Brian R Amman Tara K Sealy Serena A Reeder Carroll James A Comer Alan Kemp Robert Swanepoel Christopher D Paddock Stephen Balinandi Marina L Khristova Pierre B H Formenty Cesar G Albarino David M Miller Zachary D Reed John T Kayiwa James N Mills Deborah L Cannon Patricia W Greer Emmanuel Byaruhanga Eileen C Farnon Patrick Atimnedi Samuel Okware Edward Katongole-Mbidde Robert Downing Jordan W Tappero Sherif R Zaki Thomas G Ksiazek Stuart T Nichol Pierre E Rollin
author_sort	Jonathan S Towner
title	Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
title_short	Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
title_full	Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
title_fullStr	Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
title_full_unstemmed	Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.
title_sort	isolation of genetically diverse marburg viruses from egyptian fruit bats.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/48c76fd0d0f24675a8685e80939b4f49
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Isolation of genetically diverse Marburg viruses from Egyptian fruit bats.

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