HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

The V3 region of HIV Env elicits broadly neutralizing antibodies (bnAbs) in patients and represents a potential vaccine antigen. Here, Fera et al. show that the structure of a synthetic V3-glycopeptide closely resembles the conformation in intact HIV Env and identify amino acids in bnAbs that are im...

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Autores principales:	Daniela Fera, Matthew S. Lee, Kevin Wiehe, R. Ryan Meyerhoff, Alessandro Piai, Mattia Bonsignori, Baptiste Aussedat, William E. Walkowicz, Therese Ton, Jeffrey O. Zhou, Samuel Danishefsky, Barton F. Haynes, Stephen C. Harrison
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
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spelling	oai:doaj.org-article:48c82e6eccb2413292faad0ffabddfee2021-12-02T16:56:52ZHIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope10.1038/s41467-018-03565-62041-1723https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03565-6https://doaj.org/toc/2041-1723The V3 region of HIV Env elicits broadly neutralizing antibodies (bnAbs) in patients and represents a potential vaccine antigen. Here, Fera et al. show that the structure of a synthetic V3-glycopeptide closely resembles the conformation in intact HIV Env and identify amino acids in bnAbs that are important for neutralization breadth.Daniela FeraMatthew S. LeeKevin WieheR. Ryan MeyerhoffAlessandro PiaiMattia BonsignoriBaptiste AussedatWilliam E. WalkowiczTherese TonJeffrey O. ZhouSamuel DanishefskyBarton F. HaynesStephen C. HarrisonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Fera Matthew S. Lee Kevin Wiehe R. Ryan Meyerhoff Alessandro Piai Mattia Bonsignori Baptiste Aussedat William E. Walkowicz Therese Ton Jeffrey O. Zhou Samuel Danishefsky Barton F. Haynes Stephen C. Harrison HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
description	The V3 region of HIV Env elicits broadly neutralizing antibodies (bnAbs) in patients and represents a potential vaccine antigen. Here, Fera et al. show that the structure of a synthetic V3-glycopeptide closely resembles the conformation in intact HIV Env and identify amino acids in bnAbs that are important for neutralization breadth.
format	article
author	Daniela Fera Matthew S. Lee Kevin Wiehe R. Ryan Meyerhoff Alessandro Piai Mattia Bonsignori Baptiste Aussedat William E. Walkowicz Therese Ton Jeffrey O. Zhou Samuel Danishefsky Barton F. Haynes Stephen C. Harrison
author_facet	Daniela Fera Matthew S. Lee Kevin Wiehe R. Ryan Meyerhoff Alessandro Piai Mattia Bonsignori Baptiste Aussedat William E. Walkowicz Therese Ton Jeffrey O. Zhou Samuel Danishefsky Barton F. Haynes Stephen C. Harrison
author_sort	Daniela Fera
title	HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
title_short	HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
title_full	HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
title_fullStr	HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
title_full_unstemmed	HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
title_sort	hiv envelope v3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/48c82e6eccb2413292faad0ffabddfee
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HIV envelope V3 region mimic embodies key features of a broadly neutralizing antibody lineage epitope

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