A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1

Abstract The Caenorhabditis elegans clk-1 gene and the orthologous mouse gene Mclk1 encode a mitochondrial hydroxylase that is necessary for the biosynthesis of ubiquinone (UQ). Mutations in these genes produce broadly pleiotropic phenotypes in both species, including a lengthening of animal lifespa...

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Autores principales: Ju-Ling Liu, Callista Yee, Ying Wang, Siegfried Hekimi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/48cfd64f41a4454ca95fb1e221c9305e
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