A single biochemical activity underlies the pleiotropy of the aging-related protein CLK-1
Abstract The Caenorhabditis elegans clk-1 gene and the orthologous mouse gene Mclk1 encode a mitochondrial hydroxylase that is necessary for the biosynthesis of ubiquinone (UQ). Mutations in these genes produce broadly pleiotropic phenotypes in both species, including a lengthening of animal lifespa...
Guardado en:
Autores principales: | Ju-Ling Liu, Callista Yee, Ying Wang, Siegfried Hekimi |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/48cfd64f41a4454ca95fb1e221c9305e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
por: Simon Uzor, et al.
Publicado: (2021) -
Dibenzofuran Derivatives Inspired from Cercosporamide as Dual Inhibitors of Pim and CLK1 Kinases
por: Viet Hung Dao, et al.
Publicado: (2021) -
ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities
por: Sanjeev Kumar Sagwal, et al.
Publicado: (2021) -
A CLK1-KKT2 Signaling Pathway Regulating Kinetochore Assembly in Trypanosoma brucei
por: Manuel Saldivia, et al.
Publicado: (2021) -
Signatures of pleiotropy, economy and convergent evolution in a domain-resolved map of human-virus protein-protein interaction networks.
por: Sara Garamszegi, et al.
Publicado: (2013)