Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant

Danay Dupeyrón,1,2 Monique Kawakami,1 Adriana M Ferreira,1 Paolin Rocio Cáceres-Vélez,3 Jacques Rieumont,4 Ricardo Bentes Azevedo,3 José Carlos T Carvalho1 1Laboratório de Pesquisa em Fármacos, Centro de Ciências Biol&oa...

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Autores principales:	Dupeyr&oacute;n D, Kawakami M, Ferreira AM, C&aacute;ceres-V&eacute;lez PR, Rieumont J, Azevedo RB, Carvalho JCT
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/48d491a2f03d402b800b9b031abf0837
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spelling	oai:doaj.org-article:48d491a2f03d402b800b9b031abf08372021-12-02T02:04:23ZDesign of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant1176-91141178-2013https://doaj.org/article/48d491a2f03d402b800b9b031abf08372013-09-01T00:00:00Zhttp://www.dovepress.com/design-of-indomethacin-loaded-nanoparticles-effect-of-polymer-matrix-a-a14322https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Danay Dupeyrón,1,2 Monique Kawakami,1 Adriana M Ferreira,1 Paolin Rocio Cáceres-Vélez,3 Jacques Rieumont,4 Ricardo Bentes Azevedo,3 José Carlos T Carvalho1 1Laboratório de Pesquisa em Fármacos, Centro de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Brazil; 2Programa de Pós-Graduação em Biodiversidade Tropical, Universidade Federal do Amapá, Brazil; 3Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brazil; 4Departamento de Química – Física, Facultad de Química, Universidad de la Habana, Cuba Abstract: Despite recent advances in nonsteroidal anti-inflammatory drug (NSAID) formulations, the design of targeted delivery systems to improve the efficacy and reduce side effects of NSAIDs continues to be a focus of much research. Enteric nanoparticles have been recognized as a potential system to reduce gastrointestinal irritations caused by NSAIDs. The aim of this study was to evaluate the effect of EUDRAGIT® L100, polyethylene glycol, and polysorbate 80 on encapsulation efficiency of indomethacin within enteric nanoparticles. Formulations were developed based on a multilevel factorial design (three factors, two levels). The amount of polyethylene glycol was shown to be the factor that had the greatest influence on the encapsulation efficiency (evaluated response) at 95% confidence level. Some properties of nanoparticles like process yield, drug–polymer interaction, particle morphology, and in vitro dissolution profile, which could affect biological performance, have also been evaluated. Keywords: nonsteroidal anti-inflammatory, indomethacin, enteric polymer, polyethylene glycol, nanoparticlesDupeyr&oacute;n DKawakami MFerreira AMC&aacute;ceres-V&eacute;lez PRRieumont JAzevedo RBCarvalho JCTDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 3467-3477 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Dupeyr&oacute;n D Kawakami M Ferreira AM C&aacute;ceres-V&eacute;lez PR Rieumont J Azevedo RB Carvalho JCT Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
description	Danay Dupeyrón,1,2 Monique Kawakami,1 Adriana M Ferreira,1 Paolin Rocio Cáceres-Vélez,3 Jacques Rieumont,4 Ricardo Bentes Azevedo,3 José Carlos T Carvalho1 1Laboratório de Pesquisa em Fármacos, Centro de Ciências Biológicas e da Saúde, Colegiado de Farmácia, Universidade Federal do Amapá, Brazil; 2Programa de Pós-Graduação em Biodiversidade Tropical, Universidade Federal do Amapá, Brazil; 3Departamento de Genética e Morfologia, Instituto de Ciências Biológicas, Universidade de Brasília, Brazil; 4Departamento de Química – Física, Facultad de Química, Universidad de la Habana, Cuba Abstract: Despite recent advances in nonsteroidal anti-inflammatory drug (NSAID) formulations, the design of targeted delivery systems to improve the efficacy and reduce side effects of NSAIDs continues to be a focus of much research. Enteric nanoparticles have been recognized as a potential system to reduce gastrointestinal irritations caused by NSAIDs. The aim of this study was to evaluate the effect of EUDRAGIT® L100, polyethylene glycol, and polysorbate 80 on encapsulation efficiency of indomethacin within enteric nanoparticles. Formulations were developed based on a multilevel factorial design (three factors, two levels). The amount of polyethylene glycol was shown to be the factor that had the greatest influence on the encapsulation efficiency (evaluated response) at 95% confidence level. Some properties of nanoparticles like process yield, drug–polymer interaction, particle morphology, and in vitro dissolution profile, which could affect biological performance, have also been evaluated. Keywords: nonsteroidal anti-inflammatory, indomethacin, enteric polymer, polyethylene glycol, nanoparticles
format	article
author	Dupeyr&oacute;n D Kawakami M Ferreira AM C&aacute;ceres-V&eacute;lez PR Rieumont J Azevedo RB Carvalho JCT
author_facet	Dupeyr&oacute;n D Kawakami M Ferreira AM C&aacute;ceres-V&eacute;lez PR Rieumont J Azevedo RB Carvalho JCT
author_sort	Dupeyr&oacute;n D
title	Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
title_short	Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
title_full	Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
title_fullStr	Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
title_full_unstemmed	Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
title_sort	design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/48d491a2f03d402b800b9b031abf0837
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Design of indomethacin-loaded nanoparticles: effect of polymer matrix and surfactant

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