Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

Background:Background: Acrylamide [ACR] is an essential chemical that is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater, and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives, and polishes; it is known as a possible car...

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Autores principales:	El-sayed El-sayed Gawesh, Ahmed Abdelreheem Elshoura, Mohamed Abbas
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2021
Materias:	acrylamide ginger cinnamon hepatotoxicity albino Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/48d6e95f8eec4980b23334d6c70b31c2
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spelling	oai:doaj.org-article:48d6e95f8eec4980b23334d6c70b31c22021-12-02T10:46:47ZProtective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats2636-41742682-378010.21608/ijma.2020.43688.1177https://doaj.org/article/48d6e95f8eec4980b23334d6c70b31c22021-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_130873_f315ffb2d36a21edc21c854da6311cc1.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background:Background: Acrylamide [ACR] is an essential chemical that is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater, and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives, and polishes; it is known as a possible carcinogenic compound. Ginger oleoresin's hepatoprotective role can be attributed to its free radical scavenging, anti-inflammatory, and hypolipidemic activities and is partially mediated by the 6-gingerol, shogaol, and zingerone of its active component. Cinnamomum zeylanicum is used to treat many diseases and to prevent such diseases. Aim of the work:Evaluation of the effects of cinnamon and ginger extracts administration on Hepatotoxicity adult male albino rats. Materials and Methods: The groups were divided into five adult male albino rats of a local strain: Group I: acted as a control group with regular salines, group II: hepatotoxicity caused by acrylamid, groups III: hepatotoxicity plus cinnamon, group IV: hepatotoxicity plus ginger, group V: hepatotoxicity plus cinnamon and ginger. Samples for alanine aminotransferase [ALT], aspartate transfers of amino [AST], urea, creatinine, blood urea nitrogen (BUN), total cholesterol, triglyceride [TG], malondialdehyde, tumor necrosis factor α [TNF], superoxide dismutase [SOD], glutathione peroxidase [GPX], as well as total antioxidant [TAC] levels were obtained at the end of the experimental period. Results: Administration of cinnamon and ginger to hepatotoxic rats led to a significant decrease in the mean value of ALT, AST, urea, creatinine, BUN, MDA, and TNF. In addition, it is associated with a significant increase of SOD, GPX, and TAC. Conclusion: Cinnamon and ginger have a protective effect against abnormalities in hepatotoxic rats due to its several protective properties.El-sayed El-sayed GaweshAhmed Abdelreheem ElshouraMohamed AbbasAl-Azhar University, Faculty of Medicine (Damietta)articleacrylamidegingercinnamonhepatotoxicityalbinoMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 3, Iss 1, Pp 1136-1144 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acrylamide ginger cinnamon hepatotoxicity albino Medicine (General) R5-920
spellingShingle	acrylamide ginger cinnamon hepatotoxicity albino Medicine (General) R5-920 El-sayed El-sayed Gawesh Ahmed Abdelreheem Elshoura Mohamed Abbas Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats
description	Background:Background: Acrylamide [ACR] is an essential chemical that is extensively used in many industries and also in laboratories such as treatment of drinking water, wastewater, and soil, production of paper, petroleum, mine, asphalt, dyes, adhesives, and polishes; it is known as a possible carcinogenic compound. Ginger oleoresin's hepatoprotective role can be attributed to its free radical scavenging, anti-inflammatory, and hypolipidemic activities and is partially mediated by the 6-gingerol, shogaol, and zingerone of its active component. Cinnamomum zeylanicum is used to treat many diseases and to prevent such diseases. Aim of the work:Evaluation of the effects of cinnamon and ginger extracts administration on Hepatotoxicity adult male albino rats. Materials and Methods: The groups were divided into five adult male albino rats of a local strain: Group I: acted as a control group with regular salines, group II: hepatotoxicity caused by acrylamid, groups III: hepatotoxicity plus cinnamon, group IV: hepatotoxicity plus ginger, group V: hepatotoxicity plus cinnamon and ginger. Samples for alanine aminotransferase [ALT], aspartate transfers of amino [AST], urea, creatinine, blood urea nitrogen (BUN), total cholesterol, triglyceride [TG], malondialdehyde, tumor necrosis factor α [TNF], superoxide dismutase [SOD], glutathione peroxidase [GPX], as well as total antioxidant [TAC] levels were obtained at the end of the experimental period. Results: Administration of cinnamon and ginger to hepatotoxic rats led to a significant decrease in the mean value of ALT, AST, urea, creatinine, BUN, MDA, and TNF. In addition, it is associated with a significant increase of SOD, GPX, and TAC. Conclusion: Cinnamon and ginger have a protective effect against abnormalities in hepatotoxic rats due to its several protective properties.
format	article
author	El-sayed El-sayed Gawesh Ahmed Abdelreheem Elshoura Mohamed Abbas
author_facet	El-sayed El-sayed Gawesh Ahmed Abdelreheem Elshoura Mohamed Abbas
author_sort	El-sayed El-sayed Gawesh
title	Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats
title_short	Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats
title_full	Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats
title_fullStr	Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats
title_full_unstemmed	Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats
title_sort	protective effect of cinnamon and ginger on acrylamide induced hepatotoxicity in adult male albino rats
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2021
url	https://doaj.org/article/48d6e95f8eec4980b23334d6c70b31c2
work_keys_str_mv	AT elsayedelsayedgawesh protectiveeffectofcinnamonandgingeronacrylamideinducedhepatotoxicityinadultmalealbinorats AT ahmedabdelreheemelshoura protectiveeffectofcinnamonandgingeronacrylamideinducedhepatotoxicityinadultmalealbinorats AT mohamedabbas protectiveeffectofcinnamonandgingeronacrylamideinducedhepatotoxicityinadultmalealbinorats
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Protective Effect of Cinnamon and Ginger on Acrylamide Induced Hepatotoxicity in Adult Male Albino Rats

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