Protein-based antigen presentation platforms for nanoparticle vaccines

Abstract Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response. This approach has created safer vaccines but may limit vaccine efficacy due to poor immunogenicity. To combat global diseases suc...

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Autores principales:	Brian Nguyen, Niraj H. Tolia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/48d7babf85fb43848b0cf587c51a6749
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spelling	oai:doaj.org-article:48d7babf85fb43848b0cf587c51a67492021-12-02T15:54:45ZProtein-based antigen presentation platforms for nanoparticle vaccines10.1038/s41541-021-00330-72059-0105https://doaj.org/article/48d7babf85fb43848b0cf587c51a67492021-05-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00330-7https://doaj.org/toc/2059-0105Abstract Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response. This approach has created safer vaccines but may limit vaccine efficacy due to poor immunogenicity. To combat global diseases such as COVID-19, malaria, and AIDS there is a clear urgency for more effective next-generation vaccines. One approach to improve the immunogenicity of vaccines is the use of nanoparticle platforms that present a repetitive array of antigen on its surface. This technology has been shown to improve antigen presenting cell uptake, lymph node trafficking, and B-cell activation through increased avidity and particle size. With a focus on design, we summarize natural platforms, methods of antigen attachment, and advancements in generating self-assembly that have led to new engineered platforms. We further examine critical parameters that will direct the usage and development of more effective platforms.Brian NguyenNiraj H. ToliaNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Brian Nguyen Niraj H. Tolia Protein-based antigen presentation platforms for nanoparticle vaccines
description	Abstract Modern vaccine design has sought a minimalization approach, moving to the isolation of antigens from pathogens that invoke a strong neutralizing immune response. This approach has created safer vaccines but may limit vaccine efficacy due to poor immunogenicity. To combat global diseases such as COVID-19, malaria, and AIDS there is a clear urgency for more effective next-generation vaccines. One approach to improve the immunogenicity of vaccines is the use of nanoparticle platforms that present a repetitive array of antigen on its surface. This technology has been shown to improve antigen presenting cell uptake, lymph node trafficking, and B-cell activation through increased avidity and particle size. With a focus on design, we summarize natural platforms, methods of antigen attachment, and advancements in generating self-assembly that have led to new engineered platforms. We further examine critical parameters that will direct the usage and development of more effective platforms.
format	article
author	Brian Nguyen Niraj H. Tolia
author_facet	Brian Nguyen Niraj H. Tolia
author_sort	Brian Nguyen
title	Protein-based antigen presentation platforms for nanoparticle vaccines
title_short	Protein-based antigen presentation platforms for nanoparticle vaccines
title_full	Protein-based antigen presentation platforms for nanoparticle vaccines
title_fullStr	Protein-based antigen presentation platforms for nanoparticle vaccines
title_full_unstemmed	Protein-based antigen presentation platforms for nanoparticle vaccines
title_sort	protein-based antigen presentation platforms for nanoparticle vaccines
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48d7babf85fb43848b0cf587c51a6749
work_keys_str_mv	AT briannguyen proteinbasedantigenpresentationplatformsfornanoparticlevaccines AT nirajhtolia proteinbasedantigenpresentationplatformsfornanoparticlevaccines
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Protein-based antigen presentation platforms for nanoparticle vaccines

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