Epigenetic profiling for the molecular classification of metastatic brain tumors

Epigenetic profiling for the molecular classification of metastatic brain tumors

The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based class...

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Bibliographic Details
Main Authors: Javier I. J. Orozco, Theo A. Knijnenburg, Ayla O. Manughian-Peter, Matthew P. Salomon, Garni Barkhoudarian, John R. Jalas, James S. Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E. Buckland, John F. Thompson, Georgina V. Long, Charles S. Cobbs, Ilya Shmulevich, Daniel F. Kelly, Richard A. Scolyer, Dave S. B. Hoon, Diego M. Marzese
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/48d7f470aacb41c6b7ae96cfd0196169
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Summary:The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.

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