Epigenetic profiling for the molecular classification of metastatic brain tumors

The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based class...

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Autores principales:	Javier I. J. Orozco, Theo A. Knijnenburg, Ayla O. Manughian-Peter, Matthew P. Salomon, Garni Barkhoudarian, John R. Jalas, James S. Wilmott, Parvinder Hothi, Xiaowen Wang, Yuki Takasumi, Michael E. Buckland, John F. Thompson, Georgina V. Long, Charles S. Cobbs, Ilya Shmulevich, Daniel F. Kelly, Richard A. Scolyer, Dave S. B. Hoon, Diego M. Marzese
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48d7f470aacb41c6b7ae96cfd0196169
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spelling	oai:doaj.org-article:48d7f470aacb41c6b7ae96cfd01961692021-12-02T15:34:42ZEpigenetic profiling for the molecular classification of metastatic brain tumors10.1038/s41467-018-06715-y2041-1723https://doaj.org/article/48d7f470aacb41c6b7ae96cfd01961692018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06715-yhttps://doaj.org/toc/2041-1723The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.Javier I. J. OrozcoTheo A. KnijnenburgAyla O. Manughian-PeterMatthew P. SalomonGarni BarkhoudarianJohn R. JalasJames S. WilmottParvinder HothiXiaowen WangYuki TakasumiMichael E. BucklandJohn F. ThompsonGeorgina V. LongCharles S. CobbsIlya ShmulevichDaniel F. KellyRichard A. ScolyerDave S. B. HoonDiego M. MarzeseNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Javier I. J. Orozco Theo A. Knijnenburg Ayla O. Manughian-Peter Matthew P. Salomon Garni Barkhoudarian John R. Jalas James S. Wilmott Parvinder Hothi Xiaowen Wang Yuki Takasumi Michael E. Buckland John F. Thompson Georgina V. Long Charles S. Cobbs Ilya Shmulevich Daniel F. Kelly Richard A. Scolyer Dave S. B. Hoon Diego M. Marzese Epigenetic profiling for the molecular classification of metastatic brain tumors
description	The treatment of brain metastases is often limited by the ability to diagnose their origins. Here the authors generate DNA methylomes from the three most frequent types of brain metastases, identify epigenetic signatures specific to each type of metastasis and construct a DNA methylation-based classifier (BrainMETH) to advance brain metastasis diagnosis.
format	article
author	Javier I. J. Orozco Theo A. Knijnenburg Ayla O. Manughian-Peter Matthew P. Salomon Garni Barkhoudarian John R. Jalas James S. Wilmott Parvinder Hothi Xiaowen Wang Yuki Takasumi Michael E. Buckland John F. Thompson Georgina V. Long Charles S. Cobbs Ilya Shmulevich Daniel F. Kelly Richard A. Scolyer Dave S. B. Hoon Diego M. Marzese
author_facet	Javier I. J. Orozco Theo A. Knijnenburg Ayla O. Manughian-Peter Matthew P. Salomon Garni Barkhoudarian John R. Jalas James S. Wilmott Parvinder Hothi Xiaowen Wang Yuki Takasumi Michael E. Buckland John F. Thompson Georgina V. Long Charles S. Cobbs Ilya Shmulevich Daniel F. Kelly Richard A. Scolyer Dave S. B. Hoon Diego M. Marzese
author_sort	Javier I. J. Orozco
title	Epigenetic profiling for the molecular classification of metastatic brain tumors
title_short	Epigenetic profiling for the molecular classification of metastatic brain tumors
title_full	Epigenetic profiling for the molecular classification of metastatic brain tumors
title_fullStr	Epigenetic profiling for the molecular classification of metastatic brain tumors
title_full_unstemmed	Epigenetic profiling for the molecular classification of metastatic brain tumors
title_sort	epigenetic profiling for the molecular classification of metastatic brain tumors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/48d7f470aacb41c6b7ae96cfd0196169
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Epigenetic profiling for the molecular classification of metastatic brain tumors

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