Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Prostate and bladder cancer represent the two most frequently diagnosed genito-urinary malignancies. Diet has been implicated in both prostate and bladder cancer. Given their prolonged latency and high prevalence rates, both prostate and bladder cancer represent attractive candidates for dietary pre...

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Autores principales:	Felice Crocetto, Erika di Zazzo, Carlo Buonerba, Achille Aveta, Savio Domenico Pandolfo, Biagio Barone, Francesco Trama, Vincenzo Francesco Caputo, Luca Scafuri, Matteo Ferro, Vincenzo Cosimato, Ferdinando Fusco, Ciro Imbimbo, Giuseppe Di Lorenzo
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fisetin kaempferol myricetin prostate cancer bladder cancer Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/48da058874894328adb5d041255c840d
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spelling	oai:doaj.org-article:48da058874894328adb5d041255c840d2021-11-25T18:33:44ZKaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature10.3390/nu131137502072-6643https://doaj.org/article/48da058874894328adb5d041255c840d2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3750https://doaj.org/toc/2072-6643Prostate and bladder cancer represent the two most frequently diagnosed genito-urinary malignancies. Diet has been implicated in both prostate and bladder cancer. Given their prolonged latency and high prevalence rates, both prostate and bladder cancer represent attractive candidates for dietary preventive measures, including the use of nutritional supplements. Flavonols, a class of flavonoids, are commonly found in fruit and vegetables and are known for their protective effect against diabetes and cardiovascular diseases. Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies. In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer. A total of 21, 15 and 7 pre-clinical articles on bladder or prostate cancer reporting on kaempferol, fisetin and myricetin, respectively, were found, while more limited evidence was available from animal models and epidemiological studies or clinical trials. In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions.Felice CrocettoErika di ZazzoCarlo BuonerbaAchille AvetaSavio Domenico PandolfoBiagio BaroneFrancesco TramaVincenzo Francesco CaputoLuca ScafuriMatteo FerroVincenzo CosimatoFerdinando FuscoCiro ImbimboGiuseppe Di LorenzoMDPI AGarticlefisetinkaempferolmyricetinprostate cancerbladder cancerNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3750, p 3750 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fisetin kaempferol myricetin prostate cancer bladder cancer Nutrition. Foods and food supply TX341-641
spellingShingle	fisetin kaempferol myricetin prostate cancer bladder cancer Nutrition. Foods and food supply TX341-641 Felice Crocetto Erika di Zazzo Carlo Buonerba Achille Aveta Savio Domenico Pandolfo Biagio Barone Francesco Trama Vincenzo Francesco Caputo Luca Scafuri Matteo Ferro Vincenzo Cosimato Ferdinando Fusco Ciro Imbimbo Giuseppe Di Lorenzo Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
description	Prostate and bladder cancer represent the two most frequently diagnosed genito-urinary malignancies. Diet has been implicated in both prostate and bladder cancer. Given their prolonged latency and high prevalence rates, both prostate and bladder cancer represent attractive candidates for dietary preventive measures, including the use of nutritional supplements. Flavonols, a class of flavonoids, are commonly found in fruit and vegetables and are known for their protective effect against diabetes and cardiovascular diseases. Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies. In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer. A total of 21, 15 and 7 pre-clinical articles on bladder or prostate cancer reporting on kaempferol, fisetin and myricetin, respectively, were found, while more limited evidence was available from animal models and epidemiological studies or clinical trials. In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions.
format	article
author	Felice Crocetto Erika di Zazzo Carlo Buonerba Achille Aveta Savio Domenico Pandolfo Biagio Barone Francesco Trama Vincenzo Francesco Caputo Luca Scafuri Matteo Ferro Vincenzo Cosimato Ferdinando Fusco Ciro Imbimbo Giuseppe Di Lorenzo
author_facet	Felice Crocetto Erika di Zazzo Carlo Buonerba Achille Aveta Savio Domenico Pandolfo Biagio Barone Francesco Trama Vincenzo Francesco Caputo Luca Scafuri Matteo Ferro Vincenzo Cosimato Ferdinando Fusco Ciro Imbimbo Giuseppe Di Lorenzo
author_sort	Felice Crocetto
title	Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
title_short	Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
title_full	Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
title_fullStr	Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
title_full_unstemmed	Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature
title_sort	kaempferol, myricetin and fisetin in prostate and bladder cancer: a systematic review of the literature
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48da058874894328adb5d041255c840d
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Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

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