Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

Current therapeutic approaches in chronic lymphocytic leukemia (CLL) focus on the suppression of PI3K/AKT signaling. Here, the authors show that CLL cells are vulnerable to hyperactivation of the PI3K/AKT signaling pathway and suggest this as a promising concept for CLL therapy.

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Autores principales:	Veronika Ecker, Martina Stumpf, Lisa Brandmeier, Tanja Neumayer, Lisa Pfeuffer, Thomas Engleitner, Ingo Ringshausen, Nina Nelson, Manfred Jücker, Stefan Wanninger, Thorsten Zenz, Clemens Wendtner, Katrin Manske, Katja Steiger, Roland Rad, Markus Müschen, Jürgen Ruland, Maike Buchner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/48da348450fd4d8c8348861c88888a7b
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spelling	oai:doaj.org-article:48da348450fd4d8c8348861c88888a7b2021-12-02T18:06:34ZTargeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia10.1038/s41467-021-23752-22041-1723https://doaj.org/article/48da348450fd4d8c8348861c88888a7b2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23752-2https://doaj.org/toc/2041-1723Current therapeutic approaches in chronic lymphocytic leukemia (CLL) focus on the suppression of PI3K/AKT signaling. Here, the authors show that CLL cells are vulnerable to hyperactivation of the PI3K/AKT signaling pathway and suggest this as a promising concept for CLL therapy.Veronika EckerMartina StumpfLisa BrandmeierTanja NeumayerLisa PfeufferThomas EngleitnerIngo RingshausenNina NelsonManfred JückerStefan WanningerThorsten ZenzClemens WendtnerKatrin ManskeKatja SteigerRoland RadMarkus MüschenJürgen RulandMaike BuchnerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Veronika Ecker Martina Stumpf Lisa Brandmeier Tanja Neumayer Lisa Pfeuffer Thomas Engleitner Ingo Ringshausen Nina Nelson Manfred Jücker Stefan Wanninger Thorsten Zenz Clemens Wendtner Katrin Manske Katja Steiger Roland Rad Markus Müschen Jürgen Ruland Maike Buchner Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
description	Current therapeutic approaches in chronic lymphocytic leukemia (CLL) focus on the suppression of PI3K/AKT signaling. Here, the authors show that CLL cells are vulnerable to hyperactivation of the PI3K/AKT signaling pathway and suggest this as a promising concept for CLL therapy.
format	article
author	Veronika Ecker Martina Stumpf Lisa Brandmeier Tanja Neumayer Lisa Pfeuffer Thomas Engleitner Ingo Ringshausen Nina Nelson Manfred Jücker Stefan Wanninger Thorsten Zenz Clemens Wendtner Katrin Manske Katja Steiger Roland Rad Markus Müschen Jürgen Ruland Maike Buchner
author_facet	Veronika Ecker Martina Stumpf Lisa Brandmeier Tanja Neumayer Lisa Pfeuffer Thomas Engleitner Ingo Ringshausen Nina Nelson Manfred Jücker Stefan Wanninger Thorsten Zenz Clemens Wendtner Katrin Manske Katja Steiger Roland Rad Markus Müschen Jürgen Ruland Maike Buchner
author_sort	Veronika Ecker
title	Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
title_short	Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
title_full	Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
title_fullStr	Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
title_full_unstemmed	Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia
title_sort	targeted pi3k/akt-hyperactivation induces cell death in chronic lymphocytic leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48da348450fd4d8c8348861c88888a7b
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Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia

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