Dopamine, a co-regulatory component, bridges the central nervous system and the immune system

Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining physiological function in human body. In the past, most studies focused on the relationship between the dopaminergic system and neurological-related diseases. However, it has been found recently that DA is an imm...

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Autores principales:	Mingan Li, Lin Zhou, Xiaohui Sun, Yunqi Yang, Ce Zhang, Tian Wang, Fenghua Fu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Dopamine receptor Immune system Inflammation Agonist Antagonist Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/48dc20d6c01c4dee9522b85386a23f57
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spelling	oai:doaj.org-article:48dc20d6c01c4dee9522b85386a23f572021-11-28T04:28:20ZDopamine, a co-regulatory component, bridges the central nervous system and the immune system0753-332210.1016/j.biopha.2021.112458https://doaj.org/article/48dc20d6c01c4dee9522b85386a23f572022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012440https://doaj.org/toc/0753-3322Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining physiological function in human body. In the past, most studies focused on the relationship between the dopaminergic system and neurological-related diseases. However, it has been found recently that DA is an immunomodulatory mediator and many immune cells express dopamine receptors (DRs). Some immune cells can synthesize and secrete DA and then participate in regulating immune function. DRs agonists or antagonists can improve the dysfunction of immune system through classical G protein signaling pathways or other non-receptor-dependent pathways. This article will discuss the relationship between the dopaminergic system and the immune system. It will also review the use of DRs agonists or antagonists to treat chronic and acute inflammatory diseases and corresponding immunomodulatory mechanisms.Mingan LiLin ZhouXiaohui SunYunqi YangCe ZhangTian WangFenghua FuElsevierarticleDopamine receptorImmune systemInflammationAgonistAntagonistTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112458- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dopamine receptor Immune system Inflammation Agonist Antagonist Therapeutics. Pharmacology RM1-950
spellingShingle	Dopamine receptor Immune system Inflammation Agonist Antagonist Therapeutics. Pharmacology RM1-950 Mingan Li Lin Zhou Xiaohui Sun Yunqi Yang Ce Zhang Tian Wang Fenghua Fu Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
description	Dopamine (DA) is a crucial neurotransmitter that plays an important role in maintaining physiological function in human body. In the past, most studies focused on the relationship between the dopaminergic system and neurological-related diseases. However, it has been found recently that DA is an immunomodulatory mediator and many immune cells express dopamine receptors (DRs). Some immune cells can synthesize and secrete DA and then participate in regulating immune function. DRs agonists or antagonists can improve the dysfunction of immune system through classical G protein signaling pathways or other non-receptor-dependent pathways. This article will discuss the relationship between the dopaminergic system and the immune system. It will also review the use of DRs agonists or antagonists to treat chronic and acute inflammatory diseases and corresponding immunomodulatory mechanisms.
format	article
author	Mingan Li Lin Zhou Xiaohui Sun Yunqi Yang Ce Zhang Tian Wang Fenghua Fu
author_facet	Mingan Li Lin Zhou Xiaohui Sun Yunqi Yang Ce Zhang Tian Wang Fenghua Fu
author_sort	Mingan Li
title	Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
title_short	Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
title_full	Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
title_fullStr	Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
title_full_unstemmed	Dopamine, a co-regulatory component, bridges the central nervous system and the immune system
title_sort	dopamine, a co-regulatory component, bridges the central nervous system and the immune system
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/48dc20d6c01c4dee9522b85386a23f57
work_keys_str_mv	AT minganli dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem AT linzhou dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem AT xiaohuisun dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem AT yunqiyang dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem AT cezhang dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem AT tianwang dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem AT fenghuafu dopamineacoregulatorycomponentbridgesthecentralnervoussystemandtheimmunesystem
_version_	1718408375826382848

Dopamine, a co-regulatory component, bridges the central nervous system and the immune system

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