The neuropeptide substance P regulates aldosterone secretion in human adrenals

The neuropeptide substance P regulates aldosterone secretion in human adrenals

Adrenal aldosterone production is regulated by plasma angiotensin and potassium levels. Here the authors report that the neuropeptide substance P stimulates aldosterone production via neurokinin type 1 receptors (NK1R), and report a proof-of-concept placebo controlled clinical trial showing that a N...

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Autores principales: Julien Wils, Céline Duparc, Anne-Françoise Cailleux, Antoine-Guy Lopez, Caroline Guiheneuf, Isabelle Boutelet, Hadrien-Gaël Boyer, Christophe Dubessy, Saloua Cherifi, Bruno Cauliez, Françoise Gobet, Guillaume Defortescu, Jean-François Ménard, Estelle Louiset, Hervé Lefebvre
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/48ddfb7cf8b04ad380242a0ab5764f18
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spelling oai:doaj.org-article:48ddfb7cf8b04ad380242a0ab5764f182021-12-02T14:47:36ZThe neuropeptide substance P regulates aldosterone secretion in human adrenals10.1038/s41467-020-16470-82041-1723https://doaj.org/article/48ddfb7cf8b04ad380242a0ab5764f182020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16470-8https://doaj.org/toc/2041-1723Adrenal aldosterone production is regulated by plasma angiotensin and potassium levels. Here the authors report that the neuropeptide substance P stimulates aldosterone production via neurokinin type 1 receptors (NK1R), and report a proof-of-concept placebo controlled clinical trial showing that a NK1R antagonist decreases aldosterone levels.Julien WilsCéline DuparcAnne-Françoise CailleuxAntoine-Guy LopezCaroline GuiheneufIsabelle BouteletHadrien-Gaël BoyerChristophe DubessySaloua CherifiBruno CauliezFrançoise GobetGuillaume DefortescuJean-François MénardEstelle LouisetHervé LefebvreNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julien Wils
Céline Duparc
Anne-Françoise Cailleux
Antoine-Guy Lopez
Caroline Guiheneuf
Isabelle Boutelet
Hadrien-Gaël Boyer
Christophe Dubessy
Saloua Cherifi
Bruno Cauliez
Françoise Gobet
Guillaume Defortescu
Jean-François Ménard
Estelle Louiset
Hervé Lefebvre
The neuropeptide substance P regulates aldosterone secretion in human adrenals
description Adrenal aldosterone production is regulated by plasma angiotensin and potassium levels. Here the authors report that the neuropeptide substance P stimulates aldosterone production via neurokinin type 1 receptors (NK1R), and report a proof-of-concept placebo controlled clinical trial showing that a NK1R antagonist decreases aldosterone levels.
format article
author Julien Wils
Céline Duparc
Anne-Françoise Cailleux
Antoine-Guy Lopez
Caroline Guiheneuf
Isabelle Boutelet
Hadrien-Gaël Boyer
Christophe Dubessy
Saloua Cherifi
Bruno Cauliez
Françoise Gobet
Guillaume Defortescu
Jean-François Ménard
Estelle Louiset
Hervé Lefebvre
author_facet Julien Wils
Céline Duparc
Anne-Françoise Cailleux
Antoine-Guy Lopez
Caroline Guiheneuf
Isabelle Boutelet
Hadrien-Gaël Boyer
Christophe Dubessy
Saloua Cherifi
Bruno Cauliez
Françoise Gobet
Guillaume Defortescu
Jean-François Ménard
Estelle Louiset
Hervé Lefebvre
author_sort Julien Wils
title The neuropeptide substance P regulates aldosterone secretion in human adrenals
title_short The neuropeptide substance P regulates aldosterone secretion in human adrenals
title_full The neuropeptide substance P regulates aldosterone secretion in human adrenals
title_fullStr The neuropeptide substance P regulates aldosterone secretion in human adrenals
title_full_unstemmed The neuropeptide substance P regulates aldosterone secretion in human adrenals
title_sort neuropeptide substance p regulates aldosterone secretion in human adrenals
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/48ddfb7cf8b04ad380242a0ab5764f18
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