Suppression of autophagy promotes fibroblast activation in p53-deficient colorectal cancer cells
Abstract Deficiency of p53 in cancer cells activates the transformation of normal tissue fibroblasts into carcinoma-associated fibroblasts; this promotes tumor progression through a variety of mechanisms in the tumor microenvironment. The role of autophagy in carcinoma-associated fibroblasts in tumo...
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Autores principales: | Takanori Inoue, Yoshito Hayashi, Yoshiki Tsujii, Shunsuke Yoshii, Akihiko Sakatani, Keiichi Kimura, Ryotaro Uema, Minoru Kato, Hirotsugu Saiki, Shinichiro Shinzaki, Hideki Iijima, Tetsuo Takehara |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/48df2cbf95cf44b7bd7c9b24f8fb0af2 |
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