Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes

Type 1 diabetes (T1D) in the child population is the third most common chronic disease. Diabetic peripheral neuropathy (DPN) is a very disabling and silently developing complication. This prospective, observational study enrolled 182 (93 girls) patients with T1D, aged 16.5–18 years. The aim of the s...

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Autores principales:	Marta Wysocka-Mincewicz, Marta Baszyńska-Wilk, Maria Mazur, Aleksandra Byczyńska, Monika Nowacka-Gotowiec
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	type 1 diabetes neuropathy children thyroid hormones white blood count risk factors Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/48e4dfb7c4164c9d88a5400f066e55e3
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spelling	oai:doaj.org-article:48e4dfb7c4164c9d88a5400f066e55e32021-11-25T18:20:58ZThyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes10.3390/metabo111107952218-1989https://doaj.org/article/48e4dfb7c4164c9d88a5400f066e55e32021-11-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/795https://doaj.org/toc/2218-1989Type 1 diabetes (T1D) in the child population is the third most common chronic disease. Diabetic peripheral neuropathy (DPN) is a very disabling and silently developing complication. This prospective, observational study enrolled 182 (93 girls) patients with T1D, aged 16.5–18 years. The aim of the study was to assess the correlation between factors of diabetes metabolic control, blood count, thyroid hormones, thyroid-stimulating hormone (TSH), level of cortisol, vitamin D3, metabolic factors, demographic data, and nerve conduction study (NCS) parameters. We revealed that in multivariate regression models for almost all NCS parameters, beside height and diabetes duration, significant factors were basal insulin dose per kilogram of weight (BID/kg), body mass index (BMI), and thyroid hormones. For conduction velocities of the motor nerves, mean HbA1c exists in models. In all models for all NCS parameters there exists at least one parameter of peripheral white blood cell counts (predominantly monocytes). There is a significant influence of thyroid hormones, peripheral blood white cells count, and BID per weight on parameters of NCS. It is essential to take care of the proper insulin dose per weight of patients and the adequate proportion of basal to prandial insulin.Marta Wysocka-MincewiczMarta Baszyńska-WilkMaria MazurAleksandra ByczyńskaMonika Nowacka-GotowiecMDPI AGarticletype 1 diabetesneuropathychildrenthyroid hormoneswhite blood countrisk factorsMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 795, p 795 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 1 diabetes neuropathy children thyroid hormones white blood count risk factors Microbiology QR1-502
spellingShingle	type 1 diabetes neuropathy children thyroid hormones white blood count risk factors Microbiology QR1-502 Marta Wysocka-Mincewicz Marta Baszyńska-Wilk Maria Mazur Aleksandra Byczyńska Monika Nowacka-Gotowiec Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes
description	Type 1 diabetes (T1D) in the child population is the third most common chronic disease. Diabetic peripheral neuropathy (DPN) is a very disabling and silently developing complication. This prospective, observational study enrolled 182 (93 girls) patients with T1D, aged 16.5–18 years. The aim of the study was to assess the correlation between factors of diabetes metabolic control, blood count, thyroid hormones, thyroid-stimulating hormone (TSH), level of cortisol, vitamin D3, metabolic factors, demographic data, and nerve conduction study (NCS) parameters. We revealed that in multivariate regression models for almost all NCS parameters, beside height and diabetes duration, significant factors were basal insulin dose per kilogram of weight (BID/kg), body mass index (BMI), and thyroid hormones. For conduction velocities of the motor nerves, mean HbA1c exists in models. In all models for all NCS parameters there exists at least one parameter of peripheral white blood cell counts (predominantly monocytes). There is a significant influence of thyroid hormones, peripheral blood white cells count, and BID per weight on parameters of NCS. It is essential to take care of the proper insulin dose per weight of patients and the adequate proportion of basal to prandial insulin.
format	article
author	Marta Wysocka-Mincewicz Marta Baszyńska-Wilk Maria Mazur Aleksandra Byczyńska Monika Nowacka-Gotowiec
author_facet	Marta Wysocka-Mincewicz Marta Baszyńska-Wilk Maria Mazur Aleksandra Byczyńska Monika Nowacka-Gotowiec
author_sort	Marta Wysocka-Mincewicz
title	Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes
title_short	Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes
title_full	Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes
title_fullStr	Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes
title_full_unstemmed	Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes
title_sort	thyroid hormones, peripheral white blood count, and dose of basal insulin are associated with changes in nerve conduction studies in adolescents with type 1 diabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48e4dfb7c4164c9d88a5400f066e55e3
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Thyroid Hormones, Peripheral White Blood Count, and Dose of Basal Insulin Are Associated with Changes in Nerve Conduction Studies in Adolescents with Type 1 Diabetes

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