Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

Abstract Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes...

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Autores principales:	Jeffrey X. Xie, Helen Alderson, James Ritchie, Philip A. Kalra, Yanmei Xie, Kaili Ren, Hanh Nguyen, Tian Chen, Pamela Brewster, Rajesh Gupta, Lance D. Dworkin, Deepak Malhotra, Christopher J. Cooper, Jiang Tian, Steven T. Haller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48f5f24ffe304226aa5bceacf2bedcf1
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spelling	oai:doaj.org-article:48f5f24ffe304226aa5bceacf2bedcf12021-12-02T15:18:52ZCirculating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease10.1038/s41598-017-08426-82045-2322https://doaj.org/article/48f5f24ffe304226aa5bceacf2bedcf12017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08426-8https://doaj.org/toc/2045-2322Abstract Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal function in an all-cause chronic kidney disease (CKD) cohort. Stratification of subjects based on sCD40L and sCD40R individually, as well as in combination, demonstrated that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR). sCD40R was negatively associated with declines in eGFR. Baseline characteristics following stratification, including systolic blood pressure, history of diabetes mellitus or peripheral vascular disease, primary renal disease classification, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker usage were not significantly different. High sCD40L and low sCD40R were both found to be independent predictors of a decline in eGFR at 1-year follow-up (−7.57%, p = 0.014; −6.39%, p = 0.044). Our data suggest that circulating levels of sCD40L and sCD40R are associated with changes in renal function in patients with CKD. The CD40 decoy receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline.Jeffrey X. XieHelen AldersonJames RitchiePhilip A. KalraYanmei XieKaili RenHanh NguyenTian ChenPamela BrewsterRajesh GuptaLance D. DworkinDeepak MalhotraChristopher J. CooperJiang TianSteven T. HallerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeffrey X. Xie Helen Alderson James Ritchie Philip A. Kalra Yanmei Xie Kaili Ren Hanh Nguyen Tian Chen Pamela Brewster Rajesh Gupta Lance D. Dworkin Deepak Malhotra Christopher J. Cooper Jiang Tian Steven T. Haller Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
description	Abstract Soluble CD40 ligand (sCD40L) has been implicated in the development of renal injury. The CD40 receptor exists in a soluble form, sCD40R, and has been shown to function as a competitive antagonist against CD40 activation. We analyzed whether plasma levels of sCD40L and sCD40R predict changes in renal function in an all-cause chronic kidney disease (CKD) cohort. Stratification of subjects based on sCD40L and sCD40R individually, as well as in combination, demonstrated that sCD40L was directly associated with declines in estimated glomerular filtration rate (eGFR). sCD40R was negatively associated with declines in eGFR. Baseline characteristics following stratification, including systolic blood pressure, history of diabetes mellitus or peripheral vascular disease, primary renal disease classification, and angiotensin converting enzyme inhibitor or angiotensin receptor blocker usage were not significantly different. High sCD40L and low sCD40R were both found to be independent predictors of a decline in eGFR at 1-year follow-up (−7.57%, p = 0.014; −6.39%, p = 0.044). Our data suggest that circulating levels of sCD40L and sCD40R are associated with changes in renal function in patients with CKD. The CD40 decoy receptor, sCD40R, may serve as a potential therapeutic target to attenuate renal function decline.
format	article
author	Jeffrey X. Xie Helen Alderson James Ritchie Philip A. Kalra Yanmei Xie Kaili Ren Hanh Nguyen Tian Chen Pamela Brewster Rajesh Gupta Lance D. Dworkin Deepak Malhotra Christopher J. Cooper Jiang Tian Steven T. Haller
author_facet	Jeffrey X. Xie Helen Alderson James Ritchie Philip A. Kalra Yanmei Xie Kaili Ren Hanh Nguyen Tian Chen Pamela Brewster Rajesh Gupta Lance D. Dworkin Deepak Malhotra Christopher J. Cooper Jiang Tian Steven T. Haller
author_sort	Jeffrey X. Xie
title	Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_short	Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_full	Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_fullStr	Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_full_unstemmed	Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease
title_sort	circulating cd40 and scd40l predict changes in renal function in subjects with chronic kidney disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/48f5f24ffe304226aa5bceacf2bedcf1
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Circulating CD40 and sCD40L Predict Changes in Renal Function in Subjects with Chronic Kidney Disease

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