The shared genetic architecture between epidemiological and behavioral traits with lung cancer

Abstract The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (rg) and SNP heritability (h2) between...

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Autores principales:	Rowland W. Pettit, Jinyoung Byun, Younghun Han, Quinn T. Ostrom, Jacob Edelson, Kyle M. Walsh, Melissa L. Bondy, Rayjean J. Hung, James D. McKay, Christopher I. Amos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48f5fa5abd854b65a09e8928448fd58b
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spelling	oai:doaj.org-article:48f5fa5abd854b65a09e8928448fd58b2021-12-02T19:10:21ZThe shared genetic architecture between epidemiological and behavioral traits with lung cancer10.1038/s41598-021-96685-x2045-2322https://doaj.org/article/48f5fa5abd854b65a09e8928448fd58b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96685-xhttps://doaj.org/toc/2045-2322Abstract The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (rg) and SNP heritability (h2) between 347 traits and lung cancer risk using genome-wide association study summary statistics from the UKBB and OncoArray consortium. Further, we conducted analysis after removing genomic regions previously associated with smoking behaviors to mitigate potential confounding effects. We found significant negative genetic correlations between lung cancer risk and dietary behaviors, fitness metrics, educational attainment, and other psychosocial traits. Alcohol taken with meals (rg = − 0.41, h2 = 0.10, p = 1.33 × 10–16), increased fluid intelligence scores (rg = − 0.25, h2 = 0.22, p = 4.54 × 10–8), and the age at which full time education was completed (rg = − 0.45, h2 = 0.11, p = 1.24 × 10–20) demonstrated negative genetic correlation with lung cancer susceptibility. The body mass index was positively correlated with lung cancer risk (rg = 0.20, h2 = 0.25, p = 2.61 × 10–9). This analysis reveals shared genetic architecture between several traits and lung cancer predisposition. Future work should test for causal relationships and investigate common underlying genetic mechanisms across these genetically correlated traits.Rowland W. PettitJinyoung ByunYounghun HanQuinn T. OstromJacob EdelsonKyle M. WalshMelissa L. BondyRayjean J. HungJames D. McKayChristopher I. AmosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rowland W. Pettit Jinyoung Byun Younghun Han Quinn T. Ostrom Jacob Edelson Kyle M. Walsh Melissa L. Bondy Rayjean J. Hung James D. McKay Christopher I. Amos The shared genetic architecture between epidemiological and behavioral traits with lung cancer
description	Abstract The complex polygenic nature of lung cancer is not fully characterized. Our study seeks to identify novel phenotypes associated with lung cancer using cross-trait linkage disequilibrium score regression (LDSR). We measured pairwise genetic correlation (rg) and SNP heritability (h2) between 347 traits and lung cancer risk using genome-wide association study summary statistics from the UKBB and OncoArray consortium. Further, we conducted analysis after removing genomic regions previously associated with smoking behaviors to mitigate potential confounding effects. We found significant negative genetic correlations between lung cancer risk and dietary behaviors, fitness metrics, educational attainment, and other psychosocial traits. Alcohol taken with meals (rg = − 0.41, h2 = 0.10, p = 1.33 × 10–16), increased fluid intelligence scores (rg = − 0.25, h2 = 0.22, p = 4.54 × 10–8), and the age at which full time education was completed (rg = − 0.45, h2 = 0.11, p = 1.24 × 10–20) demonstrated negative genetic correlation with lung cancer susceptibility. The body mass index was positively correlated with lung cancer risk (rg = 0.20, h2 = 0.25, p = 2.61 × 10–9). This analysis reveals shared genetic architecture between several traits and lung cancer predisposition. Future work should test for causal relationships and investigate common underlying genetic mechanisms across these genetically correlated traits.
format	article
author	Rowland W. Pettit Jinyoung Byun Younghun Han Quinn T. Ostrom Jacob Edelson Kyle M. Walsh Melissa L. Bondy Rayjean J. Hung James D. McKay Christopher I. Amos
author_facet	Rowland W. Pettit Jinyoung Byun Younghun Han Quinn T. Ostrom Jacob Edelson Kyle M. Walsh Melissa L. Bondy Rayjean J. Hung James D. McKay Christopher I. Amos
author_sort	Rowland W. Pettit
title	The shared genetic architecture between epidemiological and behavioral traits with lung cancer
title_short	The shared genetic architecture between epidemiological and behavioral traits with lung cancer
title_full	The shared genetic architecture between epidemiological and behavioral traits with lung cancer
title_fullStr	The shared genetic architecture between epidemiological and behavioral traits with lung cancer
title_full_unstemmed	The shared genetic architecture between epidemiological and behavioral traits with lung cancer
title_sort	shared genetic architecture between epidemiological and behavioral traits with lung cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48f5fa5abd854b65a09e8928448fd58b
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The shared genetic architecture between epidemiological and behavioral traits with lung cancer

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