Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review

Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of e...

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Autores principales:	Chien-Heng Lin, Sheng-Shing Lin, Syuan-Yu Hong, Chieh-Ho Chen, I-Ching Chou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DRESS syndrome lamotrigine dyspnea Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/48fb7df3f8d748349553a2d3619e2454
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spelling	oai:doaj.org-article:48fb7df3f8d748349553a2d3619e24542021-11-25T17:14:59ZLamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review10.3390/children81110632227-9067https://doaj.org/article/48fb7df3f8d748349553a2d3619e24542021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1063https://doaj.org/toc/2227-9067Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.Chien-Heng LinSheng-Shing LinSyuan-Yu HongChieh-Ho ChenI-Ching ChouMDPI AGarticleDRESS syndromelamotriginedyspneaPediatricsRJ1-570ENChildren, Vol 8, Iss 1063, p 1063 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DRESS syndrome lamotrigine dyspnea Pediatrics RJ1-570
spellingShingle	DRESS syndrome lamotrigine dyspnea Pediatrics RJ1-570 Chien-Heng Lin Sheng-Shing Lin Syuan-Yu Hong Chieh-Ho Chen I-Ching Chou Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review
description	Lamotrigine is an important anticonvulsant drug. Its use, however, has been limited by the risk of potentially life-threatening dermatological reactions, such as a drug reaction with eosinophilia and systemic symptoms (DRESS). Here, we report the case of a 7-year-6-month-old girl with a history of epilepsy who developed a skin rash with dyspnoea after 2 weeks of lamotrigine treatment, with DRESS ultimately being diagnosed. After discontinuation of the offending drug and the initiation of systemic glucocorticosteroids, the DRESS symptoms were relieved and the patient was discharged in a stable condition. Anticonvulsant drugs such as lamotrigine are among the factors that induce DRESS in children. When a patient displays skin rash and systemic organ involvement following the initiation of an anticonvulsant drug, DRESS should not be overlooked as a diagnosis, and immunosuppressant drugs should be considered as an option for treating DRESS patients.
format	article
author	Chien-Heng Lin Sheng-Shing Lin Syuan-Yu Hong Chieh-Ho Chen I-Ching Chou
author_facet	Chien-Heng Lin Sheng-Shing Lin Syuan-Yu Hong Chieh-Ho Chen I-Ching Chou
author_sort	Chien-Heng Lin
title	Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review
title_short	Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review
title_full	Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review
title_fullStr	Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review
title_full_unstemmed	Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review
title_sort	lamotrigine induced dress syndrome in a child: a case report and literature review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48fb7df3f8d748349553a2d3619e2454
work_keys_str_mv	AT chienhenglin lamotrigineinduceddresssyndromeinachildacasereportandliteraturereview AT shengshinglin lamotrigineinduceddresssyndromeinachildacasereportandliteraturereview AT syuanyuhong lamotrigineinduceddresssyndromeinachildacasereportandliteraturereview AT chiehhochen lamotrigineinduceddresssyndromeinachildacasereportandliteraturereview AT ichingchou lamotrigineinduceddresssyndromeinachildacasereportandliteraturereview
_version_	1718412584690909184

Lamotrigine Induced DRESS Syndrome in a Child: A Case Report and Literature Review

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