Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder

Children with autism spectrum disorder (ASD) report a higher frequency and severity of gastrointestinal disorders (GID) than typically developing (TD) children. GID-associated discomfort increases feelings of anxiety and frustration, contributing to the severity of ASD. Emerging evidence supports th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Monia Kittana, Asma Ahmadani, Farah Al Marzooq, Amita Attlee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autism spectrum disorder dietary fat fatty acid gastrointestinal disorder gut microbiome Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/48fefe4cfe334ff8994603566a9dcdf9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:48fefe4cfe334ff8994603566a9dcdf9
record_format	dspace
spelling	oai:doaj.org-article:48fefe4cfe334ff8994603566a9dcdf92021-11-25T18:34:24ZDietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder10.3390/nu131138182072-6643https://doaj.org/article/48fefe4cfe334ff8994603566a9dcdf92021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3818https://doaj.org/toc/2072-6643Children with autism spectrum disorder (ASD) report a higher frequency and severity of gastrointestinal disorders (GID) than typically developing (TD) children. GID-associated discomfort increases feelings of anxiety and frustration, contributing to the severity of ASD. Emerging evidence supports the biological intersection of neurodevelopment and microbiome, indicating the integral contribution of GM in the development and function of the nervous system, and mental health, and disease balance. Dysbiotic GM could be a contributing factor in the pathogenesis of GID in children with ASD. High-fat diets may modulate GM through accelerated growth of bile-tolerant bacteria, altered bacterial ratios, and reduced bacterial diversity, which may increase the risk of GID. Notably, saturated fatty acids are considered to have a pronounced effect on the increase of bile-tolerant bacteria and reduction in microbial diversity. Additionally, omega-3 exerts a favorable impact on GM and gut health due to its anti-inflammatory properties. Despite inconsistencies in the data elaborated in the review, the dietary fat composition, as part of an overall dietary intervention, plays a role in modulating GID, specifically in ASD, due to the altered microbiome profile. This review emphasizes the need to conduct future experimental studies investigating the effect of diets with varying fatty acid compositions on GID-specific microbiome profiles in children with ASD.Monia KittanaAsma AhmadaniFarah Al MarzooqAmita AttleeMDPI AGarticleautism spectrum disorderdietary fatfatty acidgastrointestinal disordergut microbiomeNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3818, p 3818 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder dietary fat fatty acid gastrointestinal disorder gut microbiome Nutrition. Foods and food supply TX341-641
spellingShingle	autism spectrum disorder dietary fat fatty acid gastrointestinal disorder gut microbiome Nutrition. Foods and food supply TX341-641 Monia Kittana Asma Ahmadani Farah Al Marzooq Amita Attlee Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder
description	Children with autism spectrum disorder (ASD) report a higher frequency and severity of gastrointestinal disorders (GID) than typically developing (TD) children. GID-associated discomfort increases feelings of anxiety and frustration, contributing to the severity of ASD. Emerging evidence supports the biological intersection of neurodevelopment and microbiome, indicating the integral contribution of GM in the development and function of the nervous system, and mental health, and disease balance. Dysbiotic GM could be a contributing factor in the pathogenesis of GID in children with ASD. High-fat diets may modulate GM through accelerated growth of bile-tolerant bacteria, altered bacterial ratios, and reduced bacterial diversity, which may increase the risk of GID. Notably, saturated fatty acids are considered to have a pronounced effect on the increase of bile-tolerant bacteria and reduction in microbial diversity. Additionally, omega-3 exerts a favorable impact on GM and gut health due to its anti-inflammatory properties. Despite inconsistencies in the data elaborated in the review, the dietary fat composition, as part of an overall dietary intervention, plays a role in modulating GID, specifically in ASD, due to the altered microbiome profile. This review emphasizes the need to conduct future experimental studies investigating the effect of diets with varying fatty acid compositions on GID-specific microbiome profiles in children with ASD.
format	article
author	Monia Kittana Asma Ahmadani Farah Al Marzooq Amita Attlee
author_facet	Monia Kittana Asma Ahmadani Farah Al Marzooq Amita Attlee
author_sort	Monia Kittana
title	Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder
title_short	Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder
title_full	Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder
title_fullStr	Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder
title_full_unstemmed	Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder
title_sort	dietary fat effect on the gut microbiome, and its role in the modulation of gastrointestinal disorders in children with autism spectrum disorder
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/48fefe4cfe334ff8994603566a9dcdf9
work_keys_str_mv	AT moniakittana dietaryfateffectonthegutmicrobiomeanditsroleinthemodulationofgastrointestinaldisordersinchildrenwithautismspectrumdisorder AT asmaahmadani dietaryfateffectonthegutmicrobiomeanditsroleinthemodulationofgastrointestinaldisordersinchildrenwithautismspectrumdisorder AT farahalmarzooq dietaryfateffectonthegutmicrobiomeanditsroleinthemodulationofgastrointestinaldisordersinchildrenwithautismspectrumdisorder AT amitaattlee dietaryfateffectonthegutmicrobiomeanditsroleinthemodulationofgastrointestinaldisordersinchildrenwithautismspectrumdisorder
_version_	1718410950276546560

Dietary Fat Effect on the Gut Microbiome, and Its Role in the Modulation of Gastrointestinal Disorders in Children with Autism Spectrum Disorder

Ejemplares similares