Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex

Abstract Parieto-occipital alpha rhythms (8–12 Hz) underlie cortical excitability and influence visual performance. Whether the synchrony of intrinsic alpha rhythms in the occipital cortex can be entrained by transcranial magnetic stimulation (TMS) is an open question. We applied 4-pulse, 10-Hz rhyt...

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Autores principales:	Yong-Jun Lin, Lavanya Shukla, Laura Dugué, Antoni Valero-Cabré, Marisa Carrasco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/48ffa3f3768644d5821bd3e2d3467083
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spelling	oai:doaj.org-article:48ffa3f3768644d5821bd3e2d34670832021-12-02T18:33:55ZTranscranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex10.1038/s41598-021-96849-92045-2322https://doaj.org/article/48ffa3f3768644d5821bd3e2d34670832021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96849-9https://doaj.org/toc/2045-2322Abstract Parieto-occipital alpha rhythms (8–12 Hz) underlie cortical excitability and influence visual performance. Whether the synchrony of intrinsic alpha rhythms in the occipital cortex can be entrained by transcranial magnetic stimulation (TMS) is an open question. We applied 4-pulse, 10-Hz rhythmic TMS to entrain intrinsic alpha oscillators targeting right V1/V2, and tested four predictions with concurrent electroencephalogram (EEG): (1) progressive enhancement of entrainment across time windows, (2) output frequency specificity, (3) dependence on the intrinsic oscillation phase, and (4) input frequency specificity to individual alpha frequency (IAF) in the neural signatures. Two control conditions with an equal number of pulses and duration were arrhythmic-active and rhythmic-sham stimulation. The results confirmed the first three predictions. Rhythmic TMS bursts significantly entrained local neural activity. Near the stimulation site, evoked oscillation amplitude and inter-trial phase coherence (ITPC) were increased for 2 and 3 cycles, respectively, after the last TMS pulse. Critically, ITPC following entrainment positively correlated with IAF rather than with the degree of similarity between IAF and the input frequency (10 Hz). Thus, we entrained alpha-band activity in occipital cortex for ~ 3 cycles (~ 300 ms), and IAF predicts the strength of entrained occipital alpha phase synchrony indexed by ITPC.Yong-Jun LinLavanya ShuklaLaura DuguéAntoni Valero-CabréMarisa CarrascoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yong-Jun Lin Lavanya Shukla Laura Dugué Antoni Valero-Cabré Marisa Carrasco Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
description	Abstract Parieto-occipital alpha rhythms (8–12 Hz) underlie cortical excitability and influence visual performance. Whether the synchrony of intrinsic alpha rhythms in the occipital cortex can be entrained by transcranial magnetic stimulation (TMS) is an open question. We applied 4-pulse, 10-Hz rhythmic TMS to entrain intrinsic alpha oscillators targeting right V1/V2, and tested four predictions with concurrent electroencephalogram (EEG): (1) progressive enhancement of entrainment across time windows, (2) output frequency specificity, (3) dependence on the intrinsic oscillation phase, and (4) input frequency specificity to individual alpha frequency (IAF) in the neural signatures. Two control conditions with an equal number of pulses and duration were arrhythmic-active and rhythmic-sham stimulation. The results confirmed the first three predictions. Rhythmic TMS bursts significantly entrained local neural activity. Near the stimulation site, evoked oscillation amplitude and inter-trial phase coherence (ITPC) were increased for 2 and 3 cycles, respectively, after the last TMS pulse. Critically, ITPC following entrainment positively correlated with IAF rather than with the degree of similarity between IAF and the input frequency (10 Hz). Thus, we entrained alpha-band activity in occipital cortex for ~ 3 cycles (~ 300 ms), and IAF predicts the strength of entrained occipital alpha phase synchrony indexed by ITPC.
format	article
author	Yong-Jun Lin Lavanya Shukla Laura Dugué Antoni Valero-Cabré Marisa Carrasco
author_facet	Yong-Jun Lin Lavanya Shukla Laura Dugué Antoni Valero-Cabré Marisa Carrasco
author_sort	Yong-Jun Lin
title	Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
title_short	Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
title_full	Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
title_fullStr	Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
title_full_unstemmed	Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
title_sort	transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/48ffa3f3768644d5821bd3e2d3467083
work_keys_str_mv	AT yongjunlin transcranialmagneticstimulationentrainsalphaoscillatoryactivityinoccipitalcortex AT lavanyashukla transcranialmagneticstimulationentrainsalphaoscillatoryactivityinoccipitalcortex AT lauradugue transcranialmagneticstimulationentrainsalphaoscillatoryactivityinoccipitalcortex AT antonivalerocabre transcranialmagneticstimulationentrainsalphaoscillatoryactivityinoccipitalcortex AT marisacarrasco transcranialmagneticstimulationentrainsalphaoscillatoryactivityinoccipitalcortex
_version_	1718377916475113472

Transcranial magnetic stimulation entrains alpha oscillatory activity in occipital cortex

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