Valproic acid-exposed astrocytes impair inhibitory synapse formation and function

Valproic acid-exposed astrocytes impair inhibitory synapse formation and function

Abstract Valproic acid (VPA) is widely prescribed to treat epilepsy. Maternal VPA use is, however, clinically restricted because of the severe risk that VPA may cause neurodevelopmental disorders in offspring, such as autism spectrum disorder. Understanding the negative action of VPA may help to pre...

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Autores principales: Kotomi Takeda, Takuya Watanabe, Kohei Oyabu, Shuntaro Tsukamoto, Yuki Oba, Takafumi Nakano, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/49024c82ea48486eb29280de2989831e
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