Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+ T cells.

Guardado en:

Detalles Bibliográficos
Autores principales:	Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/490276d24a40458c86a47d3c716fb078
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:490276d24a40458c86a47d3c716fb078
record_format	dspace
spelling	oai:doaj.org-article:490276d24a40458c86a47d3c716fb0782021-12-02T16:28:52ZInterferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses10.1038/s41467-021-25218-x2041-1723https://doaj.org/article/490276d24a40458c86a47d3c716fb0782021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25218-xhttps://doaj.org/toc/2041-1723A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+ T cells.Qian ChenMairene Coto-LlerenaAleksei SuslovRaphael Dias TeixeiraIsabel FofanaSandro NuciforoMaike HofmannRobert ThimmeNina HenselVolker LohmannCharlotte K. Y. NgGeorge RosenbergerStefan WielandMarkus H. HeimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Chen Mairene Coto-Llerena Aleksei Suslov Raphael Dias Teixeira Isabel Fofana Sandro Nuciforo Maike Hofmann Robert Thimme Nina Hensel Volker Lohmann Charlotte K. Y. Ng George Rosenberger Stefan Wieland Markus H. Heim Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
description	A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+ T cells.
format	article
author	Qian Chen Mairene Coto-Llerena Aleksei Suslov Raphael Dias Teixeira Isabel Fofana Sandro Nuciforo Maike Hofmann Robert Thimme Nina Hensel Volker Lohmann Charlotte K. Y. Ng George Rosenberger Stefan Wieland Markus H. Heim
author_facet	Qian Chen Mairene Coto-Llerena Aleksei Suslov Raphael Dias Teixeira Isabel Fofana Sandro Nuciforo Maike Hofmann Robert Thimme Nina Hensel Volker Lohmann Charlotte K. Y. Ng George Rosenberger Stefan Wieland Markus H. Heim
author_sort	Qian Chen
title	Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
title_short	Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
title_full	Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
title_fullStr	Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
title_full_unstemmed	Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses
title_sort	interferon lambda 4 impairs hepatitis c viral antigen presentation and attenuates t cell responses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/490276d24a40458c86a47d3c716fb078
work_keys_str_mv	AT qianchen interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT mairenecotollerena interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT alekseisuslov interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT raphaeldiasteixeira interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT isabelfofana interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT sandronuciforo interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT maikehofmann interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT robertthimme interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT ninahensel interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT volkerlohmann interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT charlottekyng interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT georgerosenberger interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT stefanwieland interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses AT markushheim interferonlambda4impairshepatitiscviralantigenpresentationandattenuatestcellresponses
_version_	1718383927742169088

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

Ejemplares similares