Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

Interferon lambda 4 impairs hepatitis C viral antigen presentation and attenuates T cell responses

A genetic variant in the IFN-lambda 4 gene has been associated with poor hepatitis C virus prognosis but it is not clear how this functions. Here the authors show that IFN-lambda 4 promotes ER stress and inhibits presentation of HCV epitopes to CD8+ T cells.

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Bibliographic Details
Main Authors: Qian Chen, Mairene Coto-Llerena, Aleksei Suslov, Raphael Dias Teixeira, Isabel Fofana, Sandro Nuciforo, Maike Hofmann, Robert Thimme, Nina Hensel, Volker Lohmann, Charlotte K. Y. Ng, George Rosenberger, Stefan Wieland, Markus H. Heim
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Science
Q
Online Access:https://doaj.org/article/490276d24a40458c86a47d3c716fb078
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