The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old

Abstract Successful aging is likely to involve both genetic and environmental factors, but environmental toxicants that accelerate aging are not known. Human exposure to mercury is common, and mercury has genotoxic, autoimmune, and free radical effects which could contribute to age-related disorders...

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Autor principal:	Roger Pamphlett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4903a4777f884e48b831bd60153a213f
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spelling	oai:doaj.org-article:4903a4777f884e48b831bd60153a213f2021-12-02T15:10:39ZThe prevalence of inorganic mercury in human cells increases during aging but decreases in the very old10.1038/s41598-021-96359-82045-2322https://doaj.org/article/4903a4777f884e48b831bd60153a213f2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96359-8https://doaj.org/toc/2045-2322Abstract Successful aging is likely to involve both genetic and environmental factors, but environmental toxicants that accelerate aging are not known. Human exposure to mercury is common, and mercury has genotoxic, autoimmune, and free radical effects which could contribute to age-related disorders. The presence of inorganic mercury was therefore assessed in the organs of 170 people aged 1–104 years to determine the prevalence of mercury in human tissues at different ages. Mercury was found commonly in cells of the brain, kidney, thyroid, anterior pituitary, adrenal medulla and pancreas. The prevalence of mercury in these organs increased during aging but decreased in people aged over 80 years. People with mercury in one organ usually also had mercury in several others. In conclusion, the prevalence of inorganic mercury in human organs increases with age. The relative lack of tissue mercury in the very old could account for the flattened mortality rate and reduced incidence of cancer in this advanced age group. Since mercury may accelerate aging, efforts to reduce atmospheric mercury pollution could improve the chances of future successful aging.Roger PamphlettNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roger Pamphlett The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
description	Abstract Successful aging is likely to involve both genetic and environmental factors, but environmental toxicants that accelerate aging are not known. Human exposure to mercury is common, and mercury has genotoxic, autoimmune, and free radical effects which could contribute to age-related disorders. The presence of inorganic mercury was therefore assessed in the organs of 170 people aged 1–104 years to determine the prevalence of mercury in human tissues at different ages. Mercury was found commonly in cells of the brain, kidney, thyroid, anterior pituitary, adrenal medulla and pancreas. The prevalence of mercury in these organs increased during aging but decreased in people aged over 80 years. People with mercury in one organ usually also had mercury in several others. In conclusion, the prevalence of inorganic mercury in human organs increases with age. The relative lack of tissue mercury in the very old could account for the flattened mortality rate and reduced incidence of cancer in this advanced age group. Since mercury may accelerate aging, efforts to reduce atmospheric mercury pollution could improve the chances of future successful aging.
format	article
author	Roger Pamphlett
author_facet	Roger Pamphlett
author_sort	Roger Pamphlett
title	The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
title_short	The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
title_full	The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
title_fullStr	The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
title_full_unstemmed	The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
title_sort	prevalence of inorganic mercury in human cells increases during aging but decreases in the very old
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4903a4777f884e48b831bd60153a213f
work_keys_str_mv	AT rogerpamphlett theprevalenceofinorganicmercuryinhumancellsincreasesduringagingbutdecreasesintheveryold AT rogerpamphlett prevalenceofinorganicmercuryinhumancellsincreasesduringagingbutdecreasesintheveryold
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The prevalence of inorganic mercury in human cells increases during aging but decreases in the very old

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