Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-kappaB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways...
Guardado en:
Autores principales: | , , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
|
Materias: | |
Acceso en línea: | https://doaj.org/article/490526f1daf74d059290c0f4080e0328 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:490526f1daf74d059290c0f4080e0328 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:490526f1daf74d059290c0f4080e03282021-12-02T20:00:36ZEpithelial p38alpha controls immune cell recruitment in the colonic mucosa.1553-73661553-737410.1371/journal.ppat.1000934https://doaj.org/article/490526f1daf74d059290c0f4080e03282010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20532209/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-kappaB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways in immune responses in IECs are still largely unknown. Here we show that p38alpha in IECs is critical for chemokine expression, subsequent immune cell recruitment into the intestinal mucosa, and clearance of the infected pathogen. Mice with p38alpha deletion in IECs suffer from a sustained bacterial burden after inoculation with Citrobacter rodentium. These animals are normal in epithelial integrity and immune cell function, but fail to recruit CD4(+) T cells into colonic mucosal lesions. The expression of chemokines in IECs is impaired, which appears to be responsible for the impaired T cell recruitment. Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells.Young Jun KangMotoyuki OtsukaArjen van den BergLixin HongZhe HuangXiurong WuDuan-Wu ZhangBruce A VallancePeter S TobiasJiahuai HanPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 6, p e1000934 (2010) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Young Jun Kang Motoyuki Otsuka Arjen van den Berg Lixin Hong Zhe Huang Xiurong Wu Duan-Wu Zhang Bruce A Vallance Peter S Tobias Jiahuai Han Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
description |
Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-kappaB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways in immune responses in IECs are still largely unknown. Here we show that p38alpha in IECs is critical for chemokine expression, subsequent immune cell recruitment into the intestinal mucosa, and clearance of the infected pathogen. Mice with p38alpha deletion in IECs suffer from a sustained bacterial burden after inoculation with Citrobacter rodentium. These animals are normal in epithelial integrity and immune cell function, but fail to recruit CD4(+) T cells into colonic mucosal lesions. The expression of chemokines in IECs is impaired, which appears to be responsible for the impaired T cell recruitment. Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells. |
format |
article |
author |
Young Jun Kang Motoyuki Otsuka Arjen van den Berg Lixin Hong Zhe Huang Xiurong Wu Duan-Wu Zhang Bruce A Vallance Peter S Tobias Jiahuai Han |
author_facet |
Young Jun Kang Motoyuki Otsuka Arjen van den Berg Lixin Hong Zhe Huang Xiurong Wu Duan-Wu Zhang Bruce A Vallance Peter S Tobias Jiahuai Han |
author_sort |
Young Jun Kang |
title |
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
title_short |
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
title_full |
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
title_fullStr |
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
title_full_unstemmed |
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
title_sort |
epithelial p38alpha controls immune cell recruitment in the colonic mucosa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doaj.org/article/490526f1daf74d059290c0f4080e0328 |
work_keys_str_mv |
AT youngjunkang epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT motoyukiotsuka epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT arjenvandenberg epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT lixinhong epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT zhehuang epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT xiurongwu epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT duanwuzhang epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT bruceavallance epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT peterstobias epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa AT jiahuaihan epithelialp38alphacontrolsimmunecellrecruitmentinthecolonicmucosa |
_version_ |
1718375718648283136 |