Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.

Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-kappaB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways...

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Autores principales: Young Jun Kang, Motoyuki Otsuka, Arjen van den Berg, Lixin Hong, Zhe Huang, Xiurong Wu, Duan-Wu Zhang, Bruce A Vallance, Peter S Tobias, Jiahuai Han
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Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/490526f1daf74d059290c0f4080e0328
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spelling oai:doaj.org-article:490526f1daf74d059290c0f4080e03282021-12-02T20:00:36ZEpithelial p38alpha controls immune cell recruitment in the colonic mucosa.1553-73661553-737410.1371/journal.ppat.1000934https://doaj.org/article/490526f1daf74d059290c0f4080e03282010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20532209/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-kappaB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways in immune responses in IECs are still largely unknown. Here we show that p38alpha in IECs is critical for chemokine expression, subsequent immune cell recruitment into the intestinal mucosa, and clearance of the infected pathogen. Mice with p38alpha deletion in IECs suffer from a sustained bacterial burden after inoculation with Citrobacter rodentium. These animals are normal in epithelial integrity and immune cell function, but fail to recruit CD4(+) T cells into colonic mucosal lesions. The expression of chemokines in IECs is impaired, which appears to be responsible for the impaired T cell recruitment. Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells.Young Jun KangMotoyuki OtsukaArjen van den BergLixin HongZhe HuangXiurong WuDuan-Wu ZhangBruce A VallancePeter S TobiasJiahuai HanPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 6, Iss 6, p e1000934 (2010)
institution DOAJ
collection DOAJ
language EN
topic Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
spellingShingle Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Young Jun Kang
Motoyuki Otsuka
Arjen van den Berg
Lixin Hong
Zhe Huang
Xiurong Wu
Duan-Wu Zhang
Bruce A Vallance
Peter S Tobias
Jiahuai Han
Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
description Intestinal epithelial cells (IECs) compose the first barrier against microorganisms in the gastrointestinal tract. Although the NF-kappaB pathway in IECs was recently shown to be essential for epithelial integrity and intestinal immune homeostasis, the roles of other inflammatory signaling pathways in immune responses in IECs are still largely unknown. Here we show that p38alpha in IECs is critical for chemokine expression, subsequent immune cell recruitment into the intestinal mucosa, and clearance of the infected pathogen. Mice with p38alpha deletion in IECs suffer from a sustained bacterial burden after inoculation with Citrobacter rodentium. These animals are normal in epithelial integrity and immune cell function, but fail to recruit CD4(+) T cells into colonic mucosal lesions. The expression of chemokines in IECs is impaired, which appears to be responsible for the impaired T cell recruitment. Thus, p38alpha in IECs contributes to the host immune responses against enteric bacteria by the recruitment of immune cells.
format article
author Young Jun Kang
Motoyuki Otsuka
Arjen van den Berg
Lixin Hong
Zhe Huang
Xiurong Wu
Duan-Wu Zhang
Bruce A Vallance
Peter S Tobias
Jiahuai Han
author_facet Young Jun Kang
Motoyuki Otsuka
Arjen van den Berg
Lixin Hong
Zhe Huang
Xiurong Wu
Duan-Wu Zhang
Bruce A Vallance
Peter S Tobias
Jiahuai Han
author_sort Young Jun Kang
title Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
title_short Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
title_full Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
title_fullStr Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
title_full_unstemmed Epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
title_sort epithelial p38alpha controls immune cell recruitment in the colonic mucosa.
publisher Public Library of Science (PLoS)
publishDate 2010
url https://doaj.org/article/490526f1daf74d059290c0f4080e0328
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