Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study

Abstract Background Improvements in the treatment of rheumatoid arthritis (RA) have made it possible to achieve treatment goals. It has been reported that both residual synovitis caused by RA and the patients’ subjective symptoms remain even after achieving the treatment goals; however, there are li...

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Autores principales:	Masao Nawata, Kazuki Someya, Masashi Funada, Yuya Fujita, Atsushi Nagayasu, Kazuyoshi Saito, Yoshiya Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Grayscale Musculoskeletal ultrasonography Patient-reported outcomes Residual symptoms Rheumatoid arthritis Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/490f224f69ee46aba9dc3c8cabc66623
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spelling	oai:doaj.org-article:490f224f69ee46aba9dc3c8cabc666232021-11-28T12:23:32ZAssociation between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study10.1186/s41927-021-00221-32520-1026https://doaj.org/article/490f224f69ee46aba9dc3c8cabc666232021-11-01T00:00:00Zhttps://doi.org/10.1186/s41927-021-00221-3https://doaj.org/toc/2520-1026Abstract Background Improvements in the treatment of rheumatoid arthritis (RA) have made it possible to achieve treatment goals. It has been reported that both residual synovitis caused by RA and the patients’ subjective symptoms remain even after achieving the treatment goals; however, there are limited reports showing a relationship between them. Furthermore, no studies have evaluated the relationship between patient-reported outcomes (PROs) and subclinical synovitis measured by musculoskeletal ultrasonography (MSUS) in the treatment of RA. This study aimed to investigate residual symptoms and residual synovitis due to remission (REM) or low disease activity (LDA). Methods We performed MSUS on 300 patients with RA who attended our hospital for routine care, and we analysed them cross-sectionally by disease activity. Grayscale (GS) and power Doppler (PD) synovitis was evaluated in 22 bilateral hand joints using MSUS. We first performed univariate and multivariate analysis by dividing the data by disease activity. Next, we analysed each PRO in the obtained MSUS results. Results A multivariate analysis of high disease activity (HDA)/moderate disease activity (MDA) vs. LDA/ REM group identified tender joint count (TJC), pain visual analog scale (VAS) score, and presence or absence of GS score ≥ 2. The one-way analysis of the relationship between the presence or absence of GS score ≥ 2 and each PRO showed a significant difference. In contrast, a multivariate analysis of LDA vs. REM group identified TJC and fatigue VAS score. In REM, PROs alone were relevant, and there was no correlation with MSUS. Conclusion We found that the residual inflammation in the ultrasound images was associated with PROs in the LDA group, but not in the REM group. Trial registration Retrospectively registered.Masao NawataKazuki SomeyaMasashi FunadaYuya FujitaAtsushi NagayasuKazuyoshi SaitoYoshiya TanakaBMCarticleGrayscaleMusculoskeletal ultrasonographyPatient-reported outcomesResidual symptomsRheumatoid arthritisDiseases of the musculoskeletal systemRC925-935ENBMC Rheumatology, Vol 5, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Grayscale Musculoskeletal ultrasonography Patient-reported outcomes Residual symptoms Rheumatoid arthritis Diseases of the musculoskeletal system RC925-935
spellingShingle	Grayscale Musculoskeletal ultrasonography Patient-reported outcomes Residual symptoms Rheumatoid arthritis Diseases of the musculoskeletal system RC925-935 Masao Nawata Kazuki Someya Masashi Funada Yuya Fujita Atsushi Nagayasu Kazuyoshi Saito Yoshiya Tanaka Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
description	Abstract Background Improvements in the treatment of rheumatoid arthritis (RA) have made it possible to achieve treatment goals. It has been reported that both residual synovitis caused by RA and the patients’ subjective symptoms remain even after achieving the treatment goals; however, there are limited reports showing a relationship between them. Furthermore, no studies have evaluated the relationship between patient-reported outcomes (PROs) and subclinical synovitis measured by musculoskeletal ultrasonography (MSUS) in the treatment of RA. This study aimed to investigate residual symptoms and residual synovitis due to remission (REM) or low disease activity (LDA). Methods We performed MSUS on 300 patients with RA who attended our hospital for routine care, and we analysed them cross-sectionally by disease activity. Grayscale (GS) and power Doppler (PD) synovitis was evaluated in 22 bilateral hand joints using MSUS. We first performed univariate and multivariate analysis by dividing the data by disease activity. Next, we analysed each PRO in the obtained MSUS results. Results A multivariate analysis of high disease activity (HDA)/moderate disease activity (MDA) vs. LDA/ REM group identified tender joint count (TJC), pain visual analog scale (VAS) score, and presence or absence of GS score ≥ 2. The one-way analysis of the relationship between the presence or absence of GS score ≥ 2 and each PRO showed a significant difference. In contrast, a multivariate analysis of LDA vs. REM group identified TJC and fatigue VAS score. In REM, PROs alone were relevant, and there was no correlation with MSUS. Conclusion We found that the residual inflammation in the ultrasound images was associated with PROs in the LDA group, but not in the REM group. Trial registration Retrospectively registered.
format	article
author	Masao Nawata Kazuki Someya Masashi Funada Yuya Fujita Atsushi Nagayasu Kazuyoshi Saito Yoshiya Tanaka
author_facet	Masao Nawata Kazuki Someya Masashi Funada Yuya Fujita Atsushi Nagayasu Kazuyoshi Saito Yoshiya Tanaka
author_sort	Masao Nawata
title	Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
title_short	Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
title_full	Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
title_fullStr	Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
title_full_unstemmed	Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
title_sort	association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/490f224f69ee46aba9dc3c8cabc66623
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Association between ultrasound images and patient-reported outcomes in the treatment of rheumatoid arthritis: a retrospective study

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