Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.

We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-injected and KKAy obese diabetic mice. These mice were pair-fed three different types of diets, standard chow (SC, C∶P∶F = 63∶15∶22), a low carbohydrate (LC, C∶P∶F = 38∶25∶37) diet and a severely carbohydra...

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Autores principales: Keiko Handa, Kouichi Inukai, Hirohisa Onuma, Akihiko Kudo, Fumiyuki Nakagawa, Kazue Tsugawa, Atsuko Kitahara, Rie Moriya, Kazuto Takahashi, Yoshikazu Sumitani, Toshio Hosaka, Hayato Kawakami, Seiichi Oyadomari, Hitoshi Ishida
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Publicado: Public Library of Science (PLoS) 2014
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spelling oai:doaj.org-article:490f423ac4484dafbadb5bb6fe48819d2021-11-25T06:02:33ZLong-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.1932-620310.1371/journal.pone.0104948https://doaj.org/article/490f423ac4484dafbadb5bb6fe48819d2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25170869/?tool=EBIhttps://doaj.org/toc/1932-6203We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-injected and KKAy obese diabetic mice. These mice were pair-fed three different types of diets, standard chow (SC, C∶P∶F = 63∶15∶22), a low carbohydrate (LC, C∶P∶F = 38∶25∶37) diet and a severely carbohydrate restricted (SR, C∶P∶F = 18∶45∶37) diet for 16 weeks. Despite comparable body weights and serum lipid profiles, wild type and diabetic mice fed the low carbohydrate diets exhibited lower insulin sensitivity and this reduction was dependent on the amount of carbohydrate in the diet. When serum fatty acid compositions were investigated, monounsaturation capacity, i.e. C16:1/C16:0 and C18:1/C18:0, was impaired in all murine models fed the low carbohydrate diets, consistent with the decreased expression of hepatic stearoyl-CoA desaturase-1 (SCD1). Interestingly, both the hepatic expressions and serum levels of fibroblast growth factor 21 (FGF21), which might be related to longevity, were markedly decreased in both wild type and KKAy mice fed the SR diet. Taking into consideration that fat compositions did not differ between the LC and SR diets, we conclude that low carbohydrate diets have deleterious metabolic effects in both wild type and diabetic mice, which may explain the association between diets relatively low in carbohydrate and the elevated risk of cardiovascular events observed in clinical studies.Keiko HandaKouichi InukaiHirohisa OnumaAkihiko KudoFumiyuki NakagawaKazue TsugawaAtsuko KitaharaRie MoriyaKazuto TakahashiYoshikazu SumitaniToshio HosakaHayato KawakamiSeiichi OyadomariHitoshi IshidaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104948 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Keiko Handa
Kouichi Inukai
Hirohisa Onuma
Akihiko Kudo
Fumiyuki Nakagawa
Kazue Tsugawa
Atsuko Kitahara
Rie Moriya
Kazuto Takahashi
Yoshikazu Sumitani
Toshio Hosaka
Hayato Kawakami
Seiichi Oyadomari
Hitoshi Ishida
Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
description We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-injected and KKAy obese diabetic mice. These mice were pair-fed three different types of diets, standard chow (SC, C∶P∶F = 63∶15∶22), a low carbohydrate (LC, C∶P∶F = 38∶25∶37) diet and a severely carbohydrate restricted (SR, C∶P∶F = 18∶45∶37) diet for 16 weeks. Despite comparable body weights and serum lipid profiles, wild type and diabetic mice fed the low carbohydrate diets exhibited lower insulin sensitivity and this reduction was dependent on the amount of carbohydrate in the diet. When serum fatty acid compositions were investigated, monounsaturation capacity, i.e. C16:1/C16:0 and C18:1/C18:0, was impaired in all murine models fed the low carbohydrate diets, consistent with the decreased expression of hepatic stearoyl-CoA desaturase-1 (SCD1). Interestingly, both the hepatic expressions and serum levels of fibroblast growth factor 21 (FGF21), which might be related to longevity, were markedly decreased in both wild type and KKAy mice fed the SR diet. Taking into consideration that fat compositions did not differ between the LC and SR diets, we conclude that low carbohydrate diets have deleterious metabolic effects in both wild type and diabetic mice, which may explain the association between diets relatively low in carbohydrate and the elevated risk of cardiovascular events observed in clinical studies.
format article
author Keiko Handa
Kouichi Inukai
Hirohisa Onuma
Akihiko Kudo
Fumiyuki Nakagawa
Kazue Tsugawa
Atsuko Kitahara
Rie Moriya
Kazuto Takahashi
Yoshikazu Sumitani
Toshio Hosaka
Hayato Kawakami
Seiichi Oyadomari
Hitoshi Ishida
author_facet Keiko Handa
Kouichi Inukai
Hirohisa Onuma
Akihiko Kudo
Fumiyuki Nakagawa
Kazue Tsugawa
Atsuko Kitahara
Rie Moriya
Kazuto Takahashi
Yoshikazu Sumitani
Toshio Hosaka
Hayato Kawakami
Seiichi Oyadomari
Hitoshi Ishida
author_sort Keiko Handa
title Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
title_short Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
title_full Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
title_fullStr Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
title_full_unstemmed Long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
title_sort long-term low carbohydrate diet leads to deleterious metabolic manifestations in diabetic mice.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/490f423ac4484dafbadb5bb6fe48819d
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