The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.

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Autores principales:	S. Di Blasio, G. F. van Wigcheren, A. Becker, A. van Duffelen, M. Gorris, K. Verrijp, I. Stefanini, G. J. Bakker, M. Bloemendal, A. Halilovic, A. Vasaturo, G. Bakdash, S. V. Hato, J. H. W. de Wilt, J. Schalkwijk, I. J. M. de Vries, J. C. Textor, E. H. van den Bogaard, M. Tazzari, C. G. Figdor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4912ea5cb8dc4dbe8e21641064d96ed2
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spelling	oai:doaj.org-article:4912ea5cb8dc4dbe8e21641064d96ed22021-12-02T17:51:11ZThe tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture10.1038/s41467-020-16583-02041-1723https://doaj.org/article/4912ea5cb8dc4dbe8e21641064d96ed22020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16583-0https://doaj.org/toc/2041-1723Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.S. Di BlasioG. F. van WigcherenA. BeckerA. van DuffelenM. GorrisK. VerrijpI. StefaniniG. J. BakkerM. BloemendalA. HalilovicA. VasaturoG. BakdashS. V. HatoJ. H. W. de WiltJ. SchalkwijkI. J. M. de VriesJ. C. TextorE. H. van den BogaardM. TazzariC. G. FigdorNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Di Blasio G. F. van Wigcheren A. Becker A. van Duffelen M. Gorris K. Verrijp I. Stefanini G. J. Bakker M. Bloemendal A. Halilovic A. Vasaturo G. Bakdash S. V. Hato J. H. W. de Wilt J. Schalkwijk I. J. M. de Vries J. C. Textor E. H. van den Bogaard M. Tazzari C. G. Figdor The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
description	Conventional co-culture systems often lack physiological complexity of the tumor microenvironment. Here, the authors report an organotypic skin melanoma culture and use this model to investigate the tumor induced suppression on dendritic cells.
format	article
author	S. Di Blasio G. F. van Wigcheren A. Becker A. van Duffelen M. Gorris K. Verrijp I. Stefanini G. J. Bakker M. Bloemendal A. Halilovic A. Vasaturo G. Bakdash S. V. Hato J. H. W. de Wilt J. Schalkwijk I. J. M. de Vries J. C. Textor E. H. van den Bogaard M. Tazzari C. G. Figdor
author_facet	S. Di Blasio G. F. van Wigcheren A. Becker A. van Duffelen M. Gorris K. Verrijp I. Stefanini G. J. Bakker M. Bloemendal A. Halilovic A. Vasaturo G. Bakdash S. V. Hato J. H. W. de Wilt J. Schalkwijk I. J. M. de Vries J. C. Textor E. H. van den Bogaard M. Tazzari C. G. Figdor
author_sort	S. Di Blasio
title	The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
title_short	The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
title_full	The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
title_fullStr	The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
title_full_unstemmed	The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
title_sort	tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/4912ea5cb8dc4dbe8e21641064d96ed2
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The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

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