Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.

Metabolic networks attempt to describe the complete suite of biochemical reactions available to an organism. One notable feature of these networks in mammals is the large number of distinct proteins that catalyze the same reaction. While the existence of these isoenzymes has long been known, their e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Michaël Bekaert, Gavin C Conant
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49132ffd5e8c4809a6e5b79ff3f3b81b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:49132ffd5e8c4809a6e5b79ff3f3b81b
record_format	dspace
spelling	oai:doaj.org-article:49132ffd5e8c4809a6e5b79ff3f3b81b2021-11-18T08:35:19ZGene duplication and phenotypic changes in the evolution of mammalian metabolic networks.1932-620310.1371/journal.pone.0087115https://doaj.org/article/49132ffd5e8c4809a6e5b79ff3f3b81b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24489850/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Metabolic networks attempt to describe the complete suite of biochemical reactions available to an organism. One notable feature of these networks in mammals is the large number of distinct proteins that catalyze the same reaction. While the existence of these isoenzymes has long been known, their evolutionary significance is still unclear. Using a phylogenetically-aware comparative genomics approach, we infer enzyme orthology networks for sixteen mammals as well as for their common ancestors. We find that the pattern of isoenzymes copy-number alterations (CNAs) in these networks is suggestive of natural selection acting on the retention of certain gene duplications. When further analyzing these data with a machine-learning approach, we found that that the pattern of CNAs is also predictive of several important phenotypic traits, including milk composition and geographic range. Integrating tools from network analyses, phylogenetics and comparative genomics both allows the prediction of phenotypes from genetic data and represents a means of unifying distinct biological disciplines.Michaël BekaertGavin C ConantPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e87115 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michaël Bekaert Gavin C Conant Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
description	Metabolic networks attempt to describe the complete suite of biochemical reactions available to an organism. One notable feature of these networks in mammals is the large number of distinct proteins that catalyze the same reaction. While the existence of these isoenzymes has long been known, their evolutionary significance is still unclear. Using a phylogenetically-aware comparative genomics approach, we infer enzyme orthology networks for sixteen mammals as well as for their common ancestors. We find that the pattern of isoenzymes copy-number alterations (CNAs) in these networks is suggestive of natural selection acting on the retention of certain gene duplications. When further analyzing these data with a machine-learning approach, we found that that the pattern of CNAs is also predictive of several important phenotypic traits, including milk composition and geographic range. Integrating tools from network analyses, phylogenetics and comparative genomics both allows the prediction of phenotypes from genetic data and represents a means of unifying distinct biological disciplines.
format	article
author	Michaël Bekaert Gavin C Conant
author_facet	Michaël Bekaert Gavin C Conant
author_sort	Michaël Bekaert
title	Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
title_short	Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
title_full	Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
title_fullStr	Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
title_full_unstemmed	Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
title_sort	gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/49132ffd5e8c4809a6e5b79ff3f3b81b
work_keys_str_mv	AT michaelbekaert geneduplicationandphenotypicchangesintheevolutionofmammalianmetabolicnetworks AT gavincconant geneduplicationandphenotypicchangesintheevolutionofmammalianmetabolicnetworks
_version_	1718421557908340736

Gene duplication and phenotypic changes in the evolution of mammalian metabolic networks.

Ejemplares similares