ATF5 deficiency causes abnormal cortical development

Abstract Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors. We previously reported that ATF5-deficient (ATF5−/−) mice exhibited behavioural abnormalities, including abnormal social interac...

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Autores principales:	Mariko Umemura, Yasuyuki Kaneko, Ryoko Tanabe, Yuji Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/49138408698143acac5e19f0a208c28b
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spelling	oai:doaj.org-article:49138408698143acac5e19f0a208c28b2021-12-02T14:25:09ZATF5 deficiency causes abnormal cortical development10.1038/s41598-021-86442-52045-2322https://doaj.org/article/49138408698143acac5e19f0a208c28b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86442-5https://doaj.org/toc/2045-2322Abstract Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors. We previously reported that ATF5-deficient (ATF5−/−) mice exhibited behavioural abnormalities, including abnormal social interactions, reduced behavioural flexibility, increased anxiety-like behaviours, and hyperactivity in novel environments. ATF5−/− mice may therefore be a useful animal model for psychiatric disorders. ATF5 is highly expressed in the ventricular zone and subventricular zone during cortical development, but its physiological role in higher-order brain structures remains unknown. To investigate the cause of abnormal behaviours exhibited by ATF5−/− mice, we analysed the embryonic cerebral cortex of ATF5−/− mice. The ATF5−/− embryonic cerebral cortex was slightly thinner and had reduced numbers of radial glial cells and neural progenitor cells, compared to a wild-type cerebral cortex. ATF5 deficiency also affected the basal processes of radial glial cells, which serve as a scaffold for radial migration during cortical development. Further, the radial migration of cortical upper layer neurons was impaired in ATF5−/− mice. These results suggest that ATF5 deficiency affects cortical development and radial migration, which may partly contribute to the observed abnormal behaviours.Mariko UmemuraYasuyuki KanekoRyoko TanabeYuji TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mariko Umemura Yasuyuki Kaneko Ryoko Tanabe Yuji Takahashi ATF5 deficiency causes abnormal cortical development
description	Abstract Activating transcription factor 5 (ATF5) is a member of the cAMP response element binding protein (CREB)/ATF family of basic leucine zipper transcription factors. We previously reported that ATF5-deficient (ATF5−/−) mice exhibited behavioural abnormalities, including abnormal social interactions, reduced behavioural flexibility, increased anxiety-like behaviours, and hyperactivity in novel environments. ATF5−/− mice may therefore be a useful animal model for psychiatric disorders. ATF5 is highly expressed in the ventricular zone and subventricular zone during cortical development, but its physiological role in higher-order brain structures remains unknown. To investigate the cause of abnormal behaviours exhibited by ATF5−/− mice, we analysed the embryonic cerebral cortex of ATF5−/− mice. The ATF5−/− embryonic cerebral cortex was slightly thinner and had reduced numbers of radial glial cells and neural progenitor cells, compared to a wild-type cerebral cortex. ATF5 deficiency also affected the basal processes of radial glial cells, which serve as a scaffold for radial migration during cortical development. Further, the radial migration of cortical upper layer neurons was impaired in ATF5−/− mice. These results suggest that ATF5 deficiency affects cortical development and radial migration, which may partly contribute to the observed abnormal behaviours.
format	article
author	Mariko Umemura Yasuyuki Kaneko Ryoko Tanabe Yuji Takahashi
author_facet	Mariko Umemura Yasuyuki Kaneko Ryoko Tanabe Yuji Takahashi
author_sort	Mariko Umemura
title	ATF5 deficiency causes abnormal cortical development
title_short	ATF5 deficiency causes abnormal cortical development
title_full	ATF5 deficiency causes abnormal cortical development
title_fullStr	ATF5 deficiency causes abnormal cortical development
title_full_unstemmed	ATF5 deficiency causes abnormal cortical development
title_sort	atf5 deficiency causes abnormal cortical development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/49138408698143acac5e19f0a208c28b
work_keys_str_mv	AT marikoumemura atf5deficiencycausesabnormalcorticaldevelopment AT yasuyukikaneko atf5deficiencycausesabnormalcorticaldevelopment AT ryokotanabe atf5deficiencycausesabnormalcorticaldevelopment AT yujitakahashi atf5deficiencycausesabnormalcorticaldevelopment
_version_	1718391423693225984

ATF5 deficiency causes abnormal cortical development

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