Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience
The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021....
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Bioscientifica
2021
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oai:doaj.org-article:4914110f40644cf49997c8beb0c313cc2021-11-10T12:09:20ZChanges in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experiencehttps://doi.org/10.1530/EC-21-03822049-3614https://doaj.org/article/4914110f40644cf49997c8beb0c313cc2021-11-01T00:00:00Zhttps://ec.bioscientifica.com/view/journals/ec/10/11/EC-21-0382.xmlhttps://doaj.org/toc/2049-3614The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years.Yuan LiuSiyi GuoJinsong WuRongai WangJinbo LiuYan LiuBin LvNan LiuLing JiangXiaoli ZhangBioscientificaarticleprimary hyperparathyroidismasymptomatic primary hyperparathyroidismchinaclinical featuresDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Connections, Vol 10, Iss 11, Pp 1428-1434 (2021) |
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primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology RC648-665 |
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primary hyperparathyroidism asymptomatic primary hyperparathyroidism china clinical features Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yuan Liu Siyi Guo Jinsong Wu Rongai Wang Jinbo Liu Yan Liu Bin Lv Nan Liu Ling Jiang Xiaoli Zhang Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| description |
The clinical presentation of primary hyperparathyroidism (PHPT) differs between patients from developed and developing countries. In China, the clinical pattern has changed over the past few decades. Our aim was to elucidate general changes in the clinical characteristics of PHPT from 2010 to 2021. We enrolled 343 patients with PHPT at the Qilu Hospital of Shandong University, Jinan, China, from January 2010 to May 2021, including both surgical and non-surgical patients. Patients were divided into two subgroups, 2010–2016 (group A, n = 152) and 2017–2021 (group B, n = 191), based on the time span. We compared clinical manifestations and laboratory result data between these two groups. The mean patient age was 52.59 ± 13.55 years, and the male-to-f emale ratio was 1:2.54. Of the 343 patients, 183 (53.35%) had symptomatic PHPT; bone pain, urolithiasis, and fatigue were the most common symptoms. Post-operative pathology showed that 96.20% of the patients had parathyroid adenoma, whereas 2.41% had parathyroid carcinoma. Great changes occurred between 2010 and 2021; the percentage of patients with asymptomatic PHPT (aPHPT) increased from 36.18% in group A to 54.97% in grou p B. Moreover, patients in group B showed significantly lower serum calcium, alkaline ph osphatase, parathyroid hormone, and urinary phosphate levels but higher serum 25-hydroxyvitamin D levels than those in group A. Clinical presentations in group B were also m ilder. In conclusion, the clinical characteristics of Chinese PHPT patients changed dramatically from 2010 to 2021, with asymptomatic PHPT (aPHPT becoming the predominant type over the last 3 years. |
| format |
article |
| author |
Yuan Liu Siyi Guo Jinsong Wu Rongai Wang Jinbo Liu Yan Liu Bin Lv Nan Liu Ling Jiang Xiaoli Zhang |
| author_facet |
Yuan Liu Siyi Guo Jinsong Wu Rongai Wang Jinbo Liu Yan Liu Bin Lv Nan Liu Ling Jiang Xiaoli Zhang |
| author_sort |
Yuan Liu |
| title |
Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| title_short |
Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| title_full |
Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| title_fullStr |
Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| title_full_unstemmed |
Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| title_sort |
changes in clinical patterns of chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience |
| publisher |
Bioscientifica |
| publishDate |
2021 |
| url |
https://doi.org/10.1530/EC-21-0382 https://doaj.org/article/4914110f40644cf49997c8beb0c313cc |
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