Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors

How endothelial to mesenchymal transition is regulated in endovascular progenitors is unclear. Here, the authors show that blocking Sox9 expression in murine endovascular progenitors regulates this transition on skin wounding, affecting the size of scarring, with changes in Rbpj having the opposite...

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Autores principales:	Jilai Zhao, Jatin Patel, Simranpreet Kaur, Seen-Ling Sim, Ho Yi Wong, Cassandra Styke, Isabella Hogan, Sam Kahler, Hamish Hamilton, Racheal Wadlow, James Dight, Ghazaleh Hashemi, Laura Sormani, Edwige Roy, Mervin C. Yoder, Mathias Francois, Kiarash Khosrotehrani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4916239cb44542b7875c762bd088d608
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spelling	oai:doaj.org-article:4916239cb44542b7875c762bd088d6082021-12-02T14:29:13ZSox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors10.1038/s41467-021-22717-92041-1723https://doaj.org/article/4916239cb44542b7875c762bd088d6082021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22717-9https://doaj.org/toc/2041-1723How endothelial to mesenchymal transition is regulated in endovascular progenitors is unclear. Here, the authors show that blocking Sox9 expression in murine endovascular progenitors regulates this transition on skin wounding, affecting the size of scarring, with changes in Rbpj having the opposite effect.Jilai ZhaoJatin PatelSimranpreet KaurSeen-Ling SimHo Yi WongCassandra StykeIsabella HoganSam KahlerHamish HamiltonRacheal WadlowJames DightGhazaleh HashemiLaura SormaniEdwige RoyMervin C. YoderMathias FrancoisKiarash KhosrotehraniNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jilai Zhao Jatin Patel Simranpreet Kaur Seen-Ling Sim Ho Yi Wong Cassandra Styke Isabella Hogan Sam Kahler Hamish Hamilton Racheal Wadlow James Dight Ghazaleh Hashemi Laura Sormani Edwige Roy Mervin C. Yoder Mathias Francois Kiarash Khosrotehrani Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
description	How endothelial to mesenchymal transition is regulated in endovascular progenitors is unclear. Here, the authors show that blocking Sox9 expression in murine endovascular progenitors regulates this transition on skin wounding, affecting the size of scarring, with changes in Rbpj having the opposite effect.
format	article
author	Jilai Zhao Jatin Patel Simranpreet Kaur Seen-Ling Sim Ho Yi Wong Cassandra Styke Isabella Hogan Sam Kahler Hamish Hamilton Racheal Wadlow James Dight Ghazaleh Hashemi Laura Sormani Edwige Roy Mervin C. Yoder Mathias Francois Kiarash Khosrotehrani
author_facet	Jilai Zhao Jatin Patel Simranpreet Kaur Seen-Ling Sim Ho Yi Wong Cassandra Styke Isabella Hogan Sam Kahler Hamish Hamilton Racheal Wadlow James Dight Ghazaleh Hashemi Laura Sormani Edwige Roy Mervin C. Yoder Mathias Francois Kiarash Khosrotehrani
author_sort	Jilai Zhao
title	Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
title_short	Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
title_full	Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
title_fullStr	Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
title_full_unstemmed	Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
title_sort	sox9 and rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/4916239cb44542b7875c762bd088d608
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Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors

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