Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk

In neurons and glia, glutamate transporters catalyse the reuptake of this neurotransmitter by coupling it with cation transport. Here the authors combine X-ray crystallography and molecular dynamics simulations of the archeal glutamate transporter GltTkto get insight into the coupled transport mecha...

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Main Authors:	Albert Guskov, Sonja Jensen, Ignacio Faustino, Siewert J. Marrink, Dirk Jan Slotboom
Format:	article
Language:	EN
Published:	Nature Portfolio 2016
Subjects:	Science Q
Online Access:	https://doaj.org/article/49168b729b4f4cfb964f5e76eb8a8c28
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spelling	oai:doaj.org-article:49168b729b4f4cfb964f5e76eb8a8c282021-12-02T17:33:08ZCoupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk10.1038/ncomms134202041-1723https://doaj.org/article/49168b729b4f4cfb964f5e76eb8a8c282016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13420https://doaj.org/toc/2041-1723In neurons and glia, glutamate transporters catalyse the reuptake of this neurotransmitter by coupling it with cation transport. Here the authors combine X-ray crystallography and molecular dynamics simulations of the archeal glutamate transporter GltTkto get insight into the coupled transport mechanism.Albert GuskovSonja JensenIgnacio FaustinoSiewert J. MarrinkDirk Jan SlotboomNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Albert Guskov Sonja Jensen Ignacio Faustino Siewert J. Marrink Dirk Jan Slotboom Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
description	In neurons and glia, glutamate transporters catalyse the reuptake of this neurotransmitter by coupling it with cation transport. Here the authors combine X-ray crystallography and molecular dynamics simulations of the archeal glutamate transporter GltTkto get insight into the coupled transport mechanism.
format	article
author	Albert Guskov Sonja Jensen Ignacio Faustino Siewert J. Marrink Dirk Jan Slotboom
author_facet	Albert Guskov Sonja Jensen Ignacio Faustino Siewert J. Marrink Dirk Jan Slotboom
author_sort	Albert Guskov
title	Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
title_short	Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
title_full	Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
title_fullStr	Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
title_full_unstemmed	Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk
title_sort	coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue glttk
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/49168b729b4f4cfb964f5e76eb8a8c28
work_keys_str_mv	AT albertguskov coupledbindingmechanismofthreesodiumionsandaspartateintheglutamatetransporterhomologueglttk AT sonjajensen coupledbindingmechanismofthreesodiumionsandaspartateintheglutamatetransporterhomologueglttk AT ignaciofaustino coupledbindingmechanismofthreesodiumionsandaspartateintheglutamatetransporterhomologueglttk AT siewertjmarrink coupledbindingmechanismofthreesodiumionsandaspartateintheglutamatetransporterhomologueglttk AT dirkjanslotboom coupledbindingmechanismofthreesodiumionsandaspartateintheglutamatetransporterhomologueglttk
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Coupled binding mechanism of three sodium ions and aspartate in the glutamate transporter homologue GltTk

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