Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling

The bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. T...

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Autores principales:	Jiechen Wang, Fengyuan Guo, Guangjin Chen, Jiwei Sun, Qingming Tang, Lili Chen
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/4919454d15b64ed5a985a720caef493a
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spelling	oai:doaj.org-article:4919454d15b64ed5a985a720caef493a2021-11-15T01:19:59ZSpatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling1687-967810.1155/2021/4307961https://doaj.org/article/4919454d15b64ed5a985a720caef493a2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/4307961https://doaj.org/toc/1687-9678The bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. The disturbances of the patterns disrupt bone matrix remodeling and cause diverse bone diseases, such as osteogenesis imperfecta (OI) and bone fracture. In addition, the main regulatory factors and inflammatory factors also follow circadian rhythms. Studies show that the circadian oscillations of these factors in bone ECM potentially influence the interactions between immune responses and bone formation. More importantly, mesenchymal stem cells (MSCs) within the specific microenvironments provide the regenerative potential for tissue remodeling. In this review, we summarize the advanced ECM spatial characteristics and the periodic patterns of bone ECM. Importantly, we focus on the intrinsic connections between the immunoinflammatory system and bone formation according to circadian rhythms of regulatory factors in bone ECM. And our research group emphasizes the multipotency of MSCs with their microenvironments. The advanced understandings of bone ECM formation patterns and MSCs contribute to providing optimal prevention and treatment strategies.Jiechen WangFengyuan GuoGuangjin ChenJiwei SunQingming TangLili ChenHindawi LimitedarticleInternal medicineRC31-1245ENStem Cells International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Internal medicine RC31-1245
spellingShingle	Internal medicine RC31-1245 Jiechen Wang Fengyuan Guo Guangjin Chen Jiwei Sun Qingming Tang Lili Chen Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
description	The bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. The disturbances of the patterns disrupt bone matrix remodeling and cause diverse bone diseases, such as osteogenesis imperfecta (OI) and bone fracture. In addition, the main regulatory factors and inflammatory factors also follow circadian rhythms. Studies show that the circadian oscillations of these factors in bone ECM potentially influence the interactions between immune responses and bone formation. More importantly, mesenchymal stem cells (MSCs) within the specific microenvironments provide the regenerative potential for tissue remodeling. In this review, we summarize the advanced ECM spatial characteristics and the periodic patterns of bone ECM. Importantly, we focus on the intrinsic connections between the immunoinflammatory system and bone formation according to circadian rhythms of regulatory factors in bone ECM. And our research group emphasizes the multipotency of MSCs with their microenvironments. The advanced understandings of bone ECM formation patterns and MSCs contribute to providing optimal prevention and treatment strategies.
format	article
author	Jiechen Wang Fengyuan Guo Guangjin Chen Jiwei Sun Qingming Tang Lili Chen
author_facet	Jiechen Wang Fengyuan Guo Guangjin Chen Jiwei Sun Qingming Tang Lili Chen
author_sort	Jiechen Wang
title	Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
title_short	Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
title_full	Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
title_fullStr	Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
title_full_unstemmed	Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling
title_sort	spatial-temporal patterns and inflammatory factors of bone matrix remodeling
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/4919454d15b64ed5a985a720caef493a
work_keys_str_mv	AT jiechenwang spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT fengyuanguo spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT guangjinchen spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT jiweisun spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT qingmingtang spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling AT lilichen spatialtemporalpatternsandinflammatoryfactorsofbonematrixremodeling
_version_	1718428919380574208

Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling

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