Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus

Ashutosh Ojha,1 Utkarsh Ojha,2 Raihan Mohammed,3 Abhinaya Chandrashekar,2 Harsh Ojha41Shobhaben Pratapbhai Patel School Of Pharmacy & Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Mumbai, India; 2Faculty of Medicine, Imperial College London, London, U...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ojha A, Ojha U, Mohammed R, Chandrashekar A, Ojha H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Type 2 Diabetes Mellitus Insulin Glucagon Glucose Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/491e87bce1114af5b10272e56519ebe8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:491e87bce1114af5b10272e56519ebe8
record_format	dspace
spelling	oai:doaj.org-article:491e87bce1114af5b10272e56519ebe82021-12-02T13:18:24ZCurrent perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus1179-1438https://doaj.org/article/491e87bce1114af5b10272e56519ebe82019-05-01T00:00:00Zhttps://www.dovepress.com/current-perspective-on-the-role-of-insulin-and-glucagon-in-the-pathoge-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Ashutosh Ojha,1 Utkarsh Ojha,2 Raihan Mohammed,3 Abhinaya Chandrashekar,2 Harsh Ojha41Shobhaben Pratapbhai Patel School Of Pharmacy & Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Mumbai, India; 2Faculty of Medicine, Imperial College London, London, UK; 3Department of Medicine, University of Cambridge, Cambridge, UK; 4Department of Life Sciences, University of Warwick, Coventry, UKAbstract: According to the World Health Organization, 422 million adults worldwide live with diabetes mellitus (DM), a significant portion of whom have type 2 diabetes. The discovery of insulin as a key regulator of glucose metabolism has revolutionized our understanding of DM and provided several therapeutic avenues. Most studies have so far predominantly focused on the role of insulin in type 2 diabetes. However, the balance between insulin and glucagon is essential in ensuring glucose homeostasis. In this review, we begin by evaluating the principal differences between insulin and glucagon with regard to their mechanism and control of their secretion. Next, we discuss their mode of action and effects on metabolism. We further explore how the two hormones impact the natural history of type 2 diabetes. Finally, we outline how current and emerging pharmacological agents attempt to exploit the properties of insulin and glucagon to benefit patients with type 2 diabetes.Keywords: type 2 diabetes mellitus, insulin, glucagon, glucoseOjha AOjha UMohammed RChandrashekar AOjha HDove Medical PressarticleType 2 Diabetes MellitusInsulinGlucagonGlucoseTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 11, Pp 57-65 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 Diabetes Mellitus Insulin Glucagon Glucose Therapeutics. Pharmacology RM1-950
spellingShingle	Type 2 Diabetes Mellitus Insulin Glucagon Glucose Therapeutics. Pharmacology RM1-950 Ojha A Ojha U Mohammed R Chandrashekar A Ojha H Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
description	Ashutosh Ojha,1 Utkarsh Ojha,2 Raihan Mohammed,3 Abhinaya Chandrashekar,2 Harsh Ojha41Shobhaben Pratapbhai Patel School Of Pharmacy & Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Mumbai, India; 2Faculty of Medicine, Imperial College London, London, UK; 3Department of Medicine, University of Cambridge, Cambridge, UK; 4Department of Life Sciences, University of Warwick, Coventry, UKAbstract: According to the World Health Organization, 422 million adults worldwide live with diabetes mellitus (DM), a significant portion of whom have type 2 diabetes. The discovery of insulin as a key regulator of glucose metabolism has revolutionized our understanding of DM and provided several therapeutic avenues. Most studies have so far predominantly focused on the role of insulin in type 2 diabetes. However, the balance between insulin and glucagon is essential in ensuring glucose homeostasis. In this review, we begin by evaluating the principal differences between insulin and glucagon with regard to their mechanism and control of their secretion. Next, we discuss their mode of action and effects on metabolism. We further explore how the two hormones impact the natural history of type 2 diabetes. Finally, we outline how current and emerging pharmacological agents attempt to exploit the properties of insulin and glucagon to benefit patients with type 2 diabetes.Keywords: type 2 diabetes mellitus, insulin, glucagon, glucose
format	article
author	Ojha A Ojha U Mohammed R Chandrashekar A Ojha H
author_facet	Ojha A Ojha U Mohammed R Chandrashekar A Ojha H
author_sort	Ojha A
title	Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
title_short	Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
title_full	Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
title_fullStr	Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
title_full_unstemmed	Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
title_sort	current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/491e87bce1114af5b10272e56519ebe8
work_keys_str_mv	AT ojhaa currentperspectiveontheroleofinsulinandglucagoninthepathogenesisandtreatmentoftype2diabetesmellitus AT ojhau currentperspectiveontheroleofinsulinandglucagoninthepathogenesisandtreatmentoftype2diabetesmellitus AT mohammedr currentperspectiveontheroleofinsulinandglucagoninthepathogenesisandtreatmentoftype2diabetesmellitus AT chandrashekara currentperspectiveontheroleofinsulinandglucagoninthepathogenesisandtreatmentoftype2diabetesmellitus AT ojhah currentperspectiveontheroleofinsulinandglucagoninthepathogenesisandtreatmentoftype2diabetesmellitus
_version_	1718393268985659392

Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus

Ejemplares similares